nucleophile


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nucleophile

 [noo´kle-o-fīl″]
an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles). adj., adj nucleophil´ic.

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil', -fīl),
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil; any reagent or substance that is attracted to a region of low electron density.
2. Relating to a nucleophil. Synonym(s): nucleophilic (1)
[nucleo- + G. philos, fond]

nucleophile

/nu·cleo·phile/ (noo´kle-o-fīl) an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).nucleophil´ic

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil, -fīl)
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil.
2. Relating to a nucleophil.
Synonym(s): nucleophilic (1) .
[nucleo- + G. philos, fond]

nucleophile

an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).
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References in periodicals archive ?
Substitution of fluorine with various chromophores can be done by using aryl nucleophiles or ethynyl nucleophiles (Scheme 1) to create a large, virtual Stokes shift, anywhere in the range of 8,000 [cm.
Data show that the sulfhydryl thiolate state is a significantly softer ([sigma]) nucleophile than either the corresponding thiol state or the other amino acid residues such as histidine or lysine.
The scientists used extrusion cooking to decontaminate aflatoxins in peanut meal by mediating starch as a plasticizer and using lysine as a nucleophile.
diacylamine were observed when the nucleophile attacking the nitrilium
The electrophilic nature of HNE and the high concentrations of endogenous available compounds (thiols and His and Lys residues) can lead to several competitive reactions among nucleophiles; thus, the accessibility of the nucleophile at a given site of HNE generation is the more relevant factor in which metabolic pathway is followed.
Evidence for the involvement of a E-cycloalkenone intermediate was obtained when irradiation was performed at low temperature, followed by addition of the nucleophile in the absence of light, which afforded the addition product in ~ 20% yield.
Futhermore, the nucleophile, methoxide, displaced all four fluoro groups from N-phenyl-3,4,5,6-tetrafluoro-phthalimide (II) to form N-phenyl-3,4,5,6-tetramethoxyphthalimide (III).
Essentially every compound targeted and prepared is new because of the difficulty inherent in other methods, and the syntheses represent another group of reactions where an anionic nucleophile is condensed with an anionic electrophile.
Construction of the desired diacid monomer (Scheme 1) started with 1, 4-addition of oxygen nucleophile [18] of to/-butyl acrylate to give (77%) the corresponding product 1, which was subsequently deprotected (formic acid) to afford (95%) diacid 2.
It was logical to assume that [alpha], [beta]-unsaturated ketone group in the each diterpenoids could undergo the nucleophilic addition with nucleophile compounds such as L-cysteine in DMEM.
It is interesting to note that [alpha], [beta]-unsaturated ketones epoxidize under strongly alkaline conditions by peroxides [14] and in these cases peroxide reacts as a nucleophile.