nucleophile


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nucleophile

 [noo´kle-o-fīl″]
an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles). adj., adj nucleophil´ic.

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil', -fīl),
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil; any reagent or substance that is attracted to a region of low electron density.
2. Relating to a nucleophil. Synonym(s): nucleophilic (1)
[nucleo- + G. philos, fond]

nucleophile

/nu·cleo·phile/ (noo´kle-o-fīl) an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).nucleophil´ic

nu·cle·o·phil

, nucleophile (nū'klē-ō-fil, -fīl)
1. The electron pair donor atom in a chemical reaction in which a pair of electrons is picked up by an electrophil.
2. Relating to a nucleophil.
Synonym(s): nucleophilic (1) .
[nucleo- + G. philos, fond]

nucleophile

an electron donor in chemical reactions involving covalent catalysis in which the donated electrons bond other chemical groups (electrophiles).
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References in periodicals archive ?
From these calculations, it appears that the nucleophile dependent counter cation has an impact on the transition state energies and course of the ethynyl substitution of F-BODIPY.
It is assumed that high nucleophilicity and high electrophilicity are in opposite ends of this scale and, therefore, a molecule that shows a low electrophilicity power can be considered as a nucleophile (Parr et al.
The electrophilic character of the central carbon in isothiocyanate is usually explored as a reactive group for biologic nucleophiles.
The ambient cathodically generated nucleophiles alkylate at both carbon and oxygen and the competition is crucially dependent on the cation (tetra-butylammonium ion or lithium ion).
ion being a weak nucleophile does not induce as much fragmentation of the GDH subunit polypeptides compared with P[O.
It provides guidance on selecting the appropriate aminating agent--whether haloamines, hydroxylamines, diazonium salts, azo compounds, or azides--for different types of carbon nucleophile.
On reaction with a nucleophile the ring structure of the anhydride opens forming the acylated product.
Conclusions: Analysis of modifications induced by glycerol on Km and Vmax values as well as on liberation velocity of the reaction products suggests a model in which low molecular weight acid phosphatase isolated from alpaca liver catalyses phosphomonoesters hydrolysis through an uni biordered mechanism, with formation of an enzyme-phosphate complex that will be splitted by water or a nucleophile such a glycerol; in this model, [k.
The Sulfinyl Moiety as an Intramolecular Nucleophile.
Solvolysis is a special type of nucleophilic substitution where the nucleophile is a solvent molecule, such as alcohols and water.
The role of the electrophile is here to form an intermediate complex with the substrate, thereby increasing its reactivity toward the desired nucleophile.
Every compound targeted and prepared is new because of the difficulty inherent in traditional and other methods, and the synthesis represents another group of reactions where an anionic nucleophile is condensed with an anionic electrophile.