nuclear receptor


Also found in: Acronyms, Encyclopedia, Wikipedia.

nuclear receptor

Any of a “superfamily” of soluble (non-membrane-bound) receptors for a constellation of physiologically active compounds (ligands), such as retinoids, steroids, thyroid hormone, vitamin D, and hypolipidemic drugs. When nuclear receptors are activated by their cognate ligand, they form dimers, bind DNA and activate transcription of relevant primary target genes.
References in periodicals archive ?
These findings also help illustrate how nuclear receptors can function outside the nucleus and how changes in both conformation and location can dramatically alter their function.
INDIGO offers the most complete list of frozen, cell-based Nuclear Receptor assay kits with 21 human and 3 nonhuman ortholog kits.
The same is true for nuclear receptors: A variety of genomic approaches have linked 37 of 48 nuclear receptors to disease, but in 2009 the focus remained on the same 3 nuclear receptors that have remained the most highly cited since the early 1990s.
com)-- In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.
In this report, we developed a new method for screening novel nuclear receptor agonists, and used it to identify new candidate ligands for FXR and RARs.
INDIGO Biosciences provides more than two dozen individual nuclear receptor reporter assays for scientists engaged in the discovery and development of novel therapeutic agents.
The nuclear receptor assay system uses proprietary mammalian reporter cells to provide high-level expression of a hybrid form of the human estrogen-related receptor gamma.
Washington, Aug 3 ( ANI ): A new study has demonstrated that the curing of weight gain, obesity, and diabetes could be as simple as keeping a nuclear receptor from being activated in a small part of the brain.
Summary: TEHRAN (FNA)- A new study mapping the structure and function of the so-called "orphan" nuclear receptor TR4, suggested that vitamin A may play a more direct role than was previously known.
The keynote lecture provides an introduction to the nuclear receptor superfamily and the remaining contributions discuss such topics as metabolic control by LXR receptors, regulation of cardiac energetic by the orphan nuclear receptors ERR-alpha and ERR-gamma, FXR and bile acids as critical modulators of metabolisms, the role of PPARs in human prediabetes, the role of the intestine in reverse cholesterol transport, NR4A nuclear receptors in the vessel wall, cholesterol as a novel target in the treatment of Alzheimer's disease, PPAR-gamma mediated effects in central nervous system disorders, and the role of the orphan nuclear receptor rev-erb-alpha in the molecular biology of circadian rhythms and cardiometabolic disease.
The Salk Institute for Biological Studies (La Jolla, CA) has patented nuclear receptor proteins isolated from the silk moth bombyx mori (bR) which are useful for the regulation of transgene expression.
the premier provider of nuclear receptor products and services for the drug discovery and biosciences industries, has launched its new branding, "KNOW INDIGO," and tagline, "The Nuclear Receptor Experts.

Full browser ?