NR0B1

(redirected from nuclear hormone receptor, AHX)

NR0B1

A gene (popularly known as DAX1) on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. NR0B1 also acts as an anti-testis gene by antagonising SRY.
 
Molecular pathology
NR0B1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
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