noxa


Also found in: Wikipedia.

Nox·a

(nokz'ah),
[MIM*604959] a critical mediator protein involved in apoptosis induced by tumor suppressor p53 and other agents in cells that are exposed to noxious stresses. The protein is encoded by the gene Noxa (for damage).

nox·a

(nok'să),
Anything that exerts a harmful influence (for example, trauma, poison).
[L. injury, fr. noceo, to injure]

noxa

(nŏk′să) plural.noxae [L., injury]
Anything harmful to health.

nox·a

(nok'să)
Anything that exerts a harmful influence (e.g., trauma, poison).
[L. injury, fr. noceo, to injure]
References in periodicals archive ?
15) BAX is specifically required for PUMA (p53-upregulated modulator of apoptosis)-mediated apoptosis, and it also participates in the death response as an indirect target of P53 through PUMA and Noxa, both implicated in P53-dependent apoptosis.
GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death.
Induction of apoptosis by ectopic expression of BH3-only member Noxa in melanoma cell lines: involvement of MAP kinase signaling pathways.
Table 1 List of various pro-apoptotic and anti-apoptotic factors involved in the sepsis Pro-apoptotic factors Anti-apoptotic factors BAX Bcl-2 Bcl-xs Bcl-xl, Bcl-Al BIM, PUMA, NOXA Inhibitor of apoptosis proteins FAS ligand Mcl-1 Tumour necrosis factor- a Ras factor- a BID, BAK Apoptosis-inducing factor p53 BAX=Bcl-2-associated X protein, Bcl=B cell lymphoma, BIM=Bcl-2-interacting moderator of cell death, PUMA=p53- upregulated modulator of apoptosis, NOXA=phorbol-12 myristate-l-acetate-induced protein, FAS=cell surface Fas receptor also known as CD95L, Mcl=M cell lymphoma, Ras=rat sarcoma, BID=BH3 interacting death domain, BAK=Bcl-2 homologous antagonist killer.
They found that, when the DNA of cells is damaged through chemotherapy or radiotherapy, two proteins called Puma and Noxa cause the eggs to die.
The proteins, known as PUMA and NOXA, trigger death in damaged cells in the ovaries.
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.
Determinations are made relating to noxa in the form of suspension powders at source (emissions).
It is demonstrated that p18 (Hamlet) interacts with p53 and stimulates the transcription of several proapoptotic p53 target genes such as PUMA and NOXA.
En otros trabajos, el estres termico incremento significativamente (p< 0,01) las concentraciones de potasio y calcio serico en vacas Holstein y Jersey, aunque tales electrolitos disminuyeron (p< 0,01) en vacas cruza cebu afectadas por la misma noxa (31).
2 MI) is the latest addition to the Surpass family of high-performance polyethylenes produced with the Advanced Sclairtech single-site catalyst technology of Noxa Chemicals, Pittsburgh.
p53-and drug-induced apoptotic responses mediated by BH3only proteins puma and noxa.