novobiocin


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novobiocin

 [no″vo-bi´o-sin]
an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. It should be kept in reserve to be used only when necessary, that is, when resistance to other agents has developed. It is effective against infections caused by penicillin-resistant microorganisms, but organisms have been able to develop resistance to novobiocin rapidly. Leukopenia in some patients and jaundice in infants have been observed after novobiocin administration.

novobiocin

(nō′və-bī′ə-sĭn)
n.
An antibiotic, C31H36N2O11, produced by the actinomycete Streptomyces nivens, used primarily in research and to treat infections by gram-positive bacteria in certain animals.

novobiocin

An antibiotic drug formerly of importance in the treatment of infections with staphylococci resistant to other antibiotics but now largely replaced by beta-lactamase resistant penicillins.

novobiocin

an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. Called also albamycin, cathomycin.
References in periodicals archive ?
Is resistance to novobiocin a reliable test for confirmation of the identification of Staphylococcus saprophyticus?
The strain DM15 showed sensitivity towards erythromycin, bacitracin, penicillin, chloramphenicol, tetracycline, carbenicillin, cephaloridine and novobiocin.
Additional biochemical tests those are useful in separating the Staphylococcus species include catalase, coagulase, growth and fermentation of mannitol salt, andresistance or susceptibility to the antibiotic novobiocin.
1 mL was inoculated into 10mL of RV broth (Oxoid CM 669 containing Novobiocin 35 mg/L) and incubated for 16-24h at 42[degrees]C.
coli and Listeria) was formulated by scientists who compared its performance with other common selective media--modified EC broth with novobiocin for E coli O157:H7, Fraser broth for Listeria, and Rappaport-Vassiliadis broth for Salmonella.
Common drugs causing immune thrombocytopenia Analgesics salicylates acetaminophen phenylbutazone Antibiotics cephalothin penicillin streptomycin aminosalicylic acid rifampin novobiocin Various sulfa drugs (chlorthalidone, furosemide) Alkaloids Quinidine Quinine Sedatives, anticonvulsants methoin troxidone chlorpromazine diphenylhydantoin meprobamate phenobarbital carbamazepine Oral hypoglycemics chlorpropamide tolbutamide Heavy metals gold mercury bismuth organic arsenicals Miscellaneous chloroquine chlorothiazide insecticides
Although BAX(R) system MP media remains an appropriate enrichment broth for beef, the labs determined that modified Tryptic Soy Broth with novobiocin (mTSB-n) should be used for dairy, meat, fruit and vegetables.
Randomized double-blinded trial of rifampin with either novobiocin or trimethoprim-sulfamethoxazole against methicillin-resistant Staphylococcus aureus colonization: prevention of antimicrobial resistance and effect of host factors on outcome.
M-Broths that were presumptive positive for Salmonella were streaked onto a xylose lysine agar base with tergitol 4 supplement (XLT4) (DIFCO) and onto brilliant-green medium with novobiocin antimicrobic supplement (BGN plates) (DIFCO).
The lab will be responsible for the national drug residue milk monitoring program, Grahn says, and will test for sulfonamides, tetracyclines, beta-lactams, novobiocin and chloraphenicol.