atypical antipsychotic

(redirected from novel antipsychotic)

atypical antipsychotic

A dibenzepine-type antipsychotic which differs from conventional antipsychotics in its paucity of extrapyramidal effects (tremor, muscle stiffness and restlessness).
Adverse effects
Insomnia, anxiety, agitation, sedation, dizziness, rhinitis, orthostatic hypotension, tachycardia, weight gain, menstrual disturbances, seizures; rarely, severe granulocytopaenia or agranulocytosis; should not be used in patients with liver, brain or circulatory defects.
Clozapine (Clozaril), ziprasidone (Geodon), loxapine (Loxitane), olanzapine (Zyprexa), resperidone (Risperdal), quetiapine (Seroquel).


(ant?i-si?kot'ik) [ anti- + psychotic]
1. Preventing or treating psychosis, e.g., schizophrenia.
2. A medication to treat psychosis.

atypical antipsychotic

Second-generation antipsychotic.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)

conventional antipsychotic

First-generation antipsychotic.

second-generation antipsychotic

An antipsychotic drug that causes increased appetite, weight gain, and adverse effects on lipids. They differ from first-generation antipsychotics in that they are less likely to cause extrapyramidal side effects or tardive dyskinesia.
Synonym: atypical antipsychotic
References in periodicals archive ?
Key clinical point: The novel antipsychotic ITI-007 met its primary endpoint in a phase II trial and showed good tolerability and safety.
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More studies are needed to define the therapeutic window of this novel antipsychotic drug.
Schulz--that allude to possible benefits of olanzapine in this population, he recently published a large negative study comparing the novel antipsychotic to placebo (Brit.
conducted randomized, double-blind, three-arm placebo-controlled study of RGH-188, a novel antipsychotic, in 389 schizophrenia patients.
The medication is halted and another novel antipsychotic is prescribed.
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As was recently demonstrated in the CATIE study conducted by the National Institute of Mental Health (NIMH), there is a significant unmet medical need for novel antipsychotic without compliance limiting side effects.

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