atypical antipsychotic

(redirected from novel antipsychotic)

atypical antipsychotic

A dibenzepine-type antipsychotic which differs from conventional antipsychotics in its paucity of extrapyramidal effects (tremor, muscle stiffness and restlessness).
 
Adverse effects
Insomnia, anxiety, agitation, sedation, dizziness, rhinitis, orthostatic hypotension, tachycardia, weight gain, menstrual disturbances, seizures; rarely, severe granulocytopaenia or agranulocytosis; should not be used in patients with liver, brain or circulatory defects.
 
Examples
Clozapine (Clozaril), ziprasidone (Geodon), loxapine (Loxitane), olanzapine (Zyprexa), resperidone (Risperdal), quetiapine (Seroquel).

antipsychotic

(ant?i-si?kot'ik) [ anti- + psychotic]
1. Preventing or treating psychosis, e.g., schizophrenia.
2. A medication to treat psychosis.

atypical antipsychotic

Second-generation antipsychotic.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)

conventional antipsychotic

First-generation antipsychotic.

second-generation antipsychotic

An antipsychotic drug that causes increased appetite, weight gain, and adverse effects on lipids. They differ from first-generation antipsychotics in that they are less likely to cause extrapyramidal side effects or tardive dyskinesia.
Synonym: atypical antipsychotic
References in periodicals archive ?
Key clinical point: The novel antipsychotic ITI-007 met its primary endpoint in a phase II trial and showed good tolerability and safety.
Sales of a Novel Antipsychotic and an Improved Rescue Therapy Will Contribute Approximately $1 Billion to the PD Market in 2023, According to Findings from Decision Resources Group
During the 10 years that he led the Oncology Clinical team, he was responsible for bringing a number of oncology products to market, including Zoladex, Casodex, Arimidex, Tomudex and Faslodex, as well as leading the Phase III program for the novel antipsychotic, Seroquel.
More studies are needed to define the therapeutic window of this novel antipsychotic drug.
Schulz--that allude to possible benefits of olanzapine in this population, he recently published a large negative study comparing the novel antipsychotic to placebo (Brit.
conducted randomized, double-blind, three-arm placebo-controlled study of RGH-188, a novel antipsychotic, in 389 schizophrenia patients.
The medication is halted and another novel antipsychotic is prescribed.
After entering into an exclusive North American license for the development and commercialization of BioLineRx's novel antipsychotic BL-1020/CYP-1020, Cypress stock prices dropped dramatically.
SAN FRANCISCO -- Lurasidone, a novel antipsychotic agent, appears to be safe and effective in acute schizophrenia and at least as good as ziprasidone in stable outpatients with schizophrenia or schizoaffective disorder, according to conclusions of several phase I and phase III clinical trials.
These two new agreements build upon the existing collaboration announced last year for a novel antipsychotic.
As was recently demonstrated in the CATIE study conducted by the National Institute of Mental Health (NIMH), there is a significant unmet medical need for novel antipsychotic without compliance limiting side effects.

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