Individuals with reciprocal translocation (2-way exchange of material between 2 nonhomologous chromosomes
, with no net gain or loss of genetic material) are phenotypically normal unless the break-points interrupt or modify the function of a gene or genes (1).
These translocations, in which nonhomologous chromosomes
exchange DNA sections, result in the repositioning of a gene (located at the chromosome breakpoint) at a foreign locus and in (1) aberrant expression of the gene or (2) expression of a novel from of the gene product.
Similar, homologous chromosomes pair whereas dissimilar, nonhomologous chromosomes