nonhomologous


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nonhomologous

(of chromosomes or chromosomal segments) containing different genes not pairing during meiosis. Compare HOMOLOGOUS CHROMOSOMES.
References in periodicals archive ?
Association of crossover points with topoisomerase I cleavage sites: a model for nonhomologous recombination.
Furthermore, we also observed that the mixing of control and mutant DNA samples and an extra denaturing/renaturing step increases the chances of HDX formation between the nonhomologous DNA strands during cross-annealing, making them more apparent and easily visualized with reduced electrophoresis time.
5 nonhomologous nt, and a 15-nt sequence homologous to the target.
By use of a nonhomologous internal standard, we eliminated heteroduplex formation during competitive RT-PCR, and we demonstrate that the heterologous RNA standard used in our study and EGFR mRNA in the sample have equal amplification efficiency.
Taking into account the fact that studies have reported a c-erbB-2 overexpression in breast cancer specimens despite the lack of gene amplification [26-28], we decided to develop an assay for quantifying c-erbB-2 gene expression by competitive RT-PCR, using a nonhomologous DNA competitor and an automated DNA sequencer.
sup][126] In the absence of exogenous template DNA, the programmable nucleases create a double strand break (DSB) in desired regions, but due to the error-prone nonhomologous end joining (NHEJ) mechanism of re-ligation, an insertion/deletion (indel) mutation is frequently created at the DSB site.
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway.
PARP inhibitors may block base excision repair mechanisms, trap PARP enzymes on damaged DNA, reduce the affinity of functioning BRCA enzymes to damaged DNA, and suppress nonhomologous end joining repair mechanisms.
After DNA damage, cells can be repaired through two mechanisms: nonhomologous end joining (NHEJ) and homologous recombination (HR).
Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway," PLOS Biology, 2017; 15 (1): e2000731 DOI: 10.
The dsDNA breaks can be repaired via homology-directed repair (HDR) or nonhomologous end-joining (NHEJ).