HMGA1

(redirected from nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y)

HMGA1

A gene on chromosome 6p21 that encodes a non-histone DNA-binding protein involved in various cellular processes, such as regulating inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. HMGA1 preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA.