nondepolarizing agents

nondepolarizing agents

anticholinergic drugs that compete with acetylcholine at cholinergic receptors. Used as muscle relaxants. Called also competitive drugs. Examples are d-tubocurarine, gallamine, pancuronium.
References in periodicals archive ?
The nondepolarizing agents are poorly lipophilic and do not penetrate well into fat tissue or across the blood-brain barrier.
All nondepolarizing agents have a tendency to release histamine from mast cells.
By preventing the binding of acetylcholine, the nondepolarizing agents block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.