noncompetitive inhibition

inhibition /in·hi·bi·tion/ (in″hĭ-bish´un)

1. arrest or restraint of a process.

2. in psychoanalytic theory, the conscious or unconscious restraining of an impulse or desire.

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competitive inhibition  inhibition of enzyme activity in which the inhibitor (a substrate analogue) competes with the substrate for binding sites on the enzymes.

contact inhibition  inhibition of cell division and cell motility in normal animal cells when in close contact with each other.

endproduct inhibition , feedback inhibition inhibition of the initial steps of a process by an endproduct of the reaction.

noncompetitive inhibition  inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

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non·com·pet·i·tive inhibition (nnkm-pt-tv)

n.

Enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme but inhibits reaction by combining with the enzyme-substrate complex after the complex is formed.

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noncompetitive inhibition

[-kəmpet′itiv]

(in pharmacology) a form of inhibition in which a substance (drug) occupying a receptor cannot be displaced from the receptor by increasing the number of other molecules through the principle of mass action. The drug is irreversibly bound to the receptor.

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inhibition

arrest or restraint of a process.

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competitive inhibition

inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.

contact inhibition

inhibition of cell division and cell motility in normal animal cells when in close contact with each other.

end-product inhibition

see feedback inhibition (below).

feedback inhibition

a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.

neurological inhibition

the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.

noncompetitive inhibition

inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.