non-Hodgkin lymphoma


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non-Hodg·kin lym·pho·ma (NHL),

a lymphoma other than Hodgkin disease, classified by Rappaport into a nodular or diffuse tumor pattern and by cell type; a working or international formulation separates such lymphomas into low-, intermediate-, and high-grade malignancy and into cytologic subtypes reflecting follicular center cell or other origin.

non-Hodgkin lymphoma

(nŏn′hŏj′kĭn) or

non-Hodgkin's lymphoma

(-kĭnz)
n.
Any of a large group of lymphomas that can be slow-growing or fast-growing, involve malignancies of either B cells or T cells, and are typically distinguished from Hodgkin lymphoma by the absence of Reed-Sternberg cells. Symptoms include enlarged lymph nodes, fever, night sweats, and weight loss.

non-Hodg·kin lym·pho·ma

(non-hoj'kin lim-fō'mă)
A lymphoma other than Hodgkin disease, classified by Rappaport into a nodular or diffuse tumor pattern and by cell type; a working or international formulation separates such lymphomas into low, intermediate, and high grade malignancy and into cytologic subtypes reflecting follicular center cell or other origin.
Enlarge picture
NON-HODGKIN LYMPHOMA: Bizarre-appearing lymphocytes revealing active mitosis (orig. mag. ×1000)

non-Hodgkin lymphoma

Abbreviation: NHL
Any of a group of malignant tumors of B or T lymphocytes. In 2008, the American Cancer Society estimated that about 66,100 Americans would be newly diagnosed with the disease. See: illustration; Hodgkin disease

Symptoms

Painless lymphadenopathy in two thirds of patients is the most frequent presenting symptom. Others have fever, night sweats, and loss of 10% or more of body weight in the 6 months before presenting with symptoms of infiltration into nonlymphoid tissue. Additional involvement is in peripheral areas such as epitrochlear nodes, the tonsillar area, and bone marrow. NHL is 50% more frequent in occurrence in men than in women of similar age. In most cases the cause of NHL is unknown, but patients who have received immunosuppressive agents have an over 100 times greater chance of developing NHL, probably because the immunosuppressive agents activate tumor viruses.

Treatment

Specific therapy depends on the type, grade, and stage of the lymphoma. Combination chemotherapies, bone marrow transplantation, radiation therapy, and photochemotherapy may be given, depending on the specific diagnosis.

See also: lymphoma

Hodgkin,

Thomas, English physician, 1798-1866.
Hodgkin disease - malignant neoplasm of lymphoid cells of uncertain origin, associated with inflammatory infiltration of lymphocytes and eosinophilic leukocytes and fibrosis. Synonym(s): lymphadenoma
Hodgkin-Key murmur - a musical diastolic murmur.
Hodgkin sarcoma
non-Hodgkin lymphoma - a lymphoma other than Hodgkin disease.

non-Hodg·kin lym·pho·ma

(non-hoj'kin lim-fō'mă)
A lymphoma other than Hodgkin disease, classified nodular or diffuse tumor pattern and cell type.
References in periodicals archive ?
Table-II: Types of Non-Hodgkin lymphoma with bone marrow infiltrate (n=70).
A number of studies have investigated the frequency and patterns of bone marrow involvement in patients of Non-Hodgkin lymphoma in various populations and have reported variable results.
Clinicopathological studies on bone marrow involvement of non-Hodgkin lymphoma.
A review of the Non-Hodgkin Lymphoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
Coverage of the Non-Hodgkin Lymphoma pipeline on the basis of route of administration and molecule type.
Identify and understand important and diverse types of therapeutics under development for Non-Hodgkin Lymphoma.
Case-control study on concentrations of organohalogen compounds and titers of antibodies to Epstein-Barr virus antigens in the etiology of non-Hodgkin lymphoma.
Adipose tissue concentrations of dioxins and dibenzofurans, titers of antibodies to Epstein-Barr virus early antigen ant the risk for non-Hodgkin lymphoma.
An Overview of Pipeline Products for Non-Hodgkin Lymphoma
Non-Hodgkin Lymphoma Therapeutics under Development by Companies
The phase Ib study will enroll patients with relapsed follicular or marginal zone non-Hodgkin lymphoma at multiple cancer centers in the U.
SGN-40 is a humanized monoclonal antibody that is currently in phase I and phase II clinical trials for non-Hodgkin lymphoma and multiple myeloma under a worldwide collaboration agreement with Genentech.

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