nitrosamines


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ni·tros·a·mines

(nī-trōs'am-ēnz),
Amines substituted by a nitroso (NO) group, usually on a nitrogen atom, to yield N-nitrosamines; can be formed by direct combination of an amine and nitrous acid (can be formed from nitrites in the acidic gastric juice); some are mutagenic and/or carcinogenic.

nitrosamines

[nīt′rəsam′ēnz]
potentially carcinogenic compounds produced by reactions of nitrites with amines or amides normally present in the body. Nitrites are produced by bacteria in saliva and in the intestine from nitrates normally present in vegetables and in nitrate-treated fish, poultry, and meats. More than 70% of ingested nitrates are from vegetables.

nitrosamines

A class of complex organic nitrogen molecules formed in the stomach by a reaction between nitrites and the amine groups of certain proteins, or else ingested pre-formed in beer and certain drugs or absorbed from cigarette smoke (the nitrosamine levels in smokers is up to eight times that of nonsmokers). Nitrosamines are carcinogenic, and are implicated in cancers of the stomach, oesophagus, nasopharynx and urinary bladder; the reaction between of nitrites and amines can be inhibited with antioxidants, such as vitamins C and E, and others.

nitrosamines

Clinical toxicology A class of complex organic nitrogen molecules, formed in the stomach by a reaction between nitrites and the amine groups of certain proteins, or ingested preformed in beer and certain drugs, or absorbed from cigarette smoke–the nitrosamine levels in smokers is up to 8-fold that of nonsmokers; the reaction between nitrites and amines can be inhibited with antioxidants–eg, vitamins C and E, etc; nitrosamines are implicated in CA of stomach, esophagus, nasopharynx, urinary bladder, etc. Cf Nitrates, Nitrites, Nitrogen, Sodium nitrate.

ni·tro·sa·mines

(nī-trō'să-mēnz)
Carcinogenic chemical compounds produced when nitrite, a preservative typically added to certain foods (especially beer, fish, fish byproducts, and certain types of meat and cheese products), combines with amino acids in the stomach. Nitrosamines can also be found in tobacco smoke and latex products.

nitrosamines

Nitrosylated secondary amines some of which can cause cancer by decomposing to form ALKYLATING AGENTS.

ni·tro·sa·mines

(nī-trō'să-mēnz)
Amines substituted by a nitroso (NO) group, usually on a nitrogen atom, to yield N-nitrosamines; some are mutagenic and/or carcinogenic.

nitrosamines

highly hepatotoxic compounds formed in the rumen by the combination of amines and nitrite. They do not appear to occur naturally in large quantities. Nitrosamine poisoning has also been caused by feeding nitrite-treated fishmeal and Solanum incanum.
References in periodicals archive ?
Finnebrogue chairman Denis Lynn said: "Bacon contains nitrites, nitrites produce nitrosamines in your gut and nitrosamines are carcinogenic.
But the vitamin C and polyphenols in vegetables make it harder for nitrosamines to form.
Concern regarding thirdhand smoke's potential public health impact ramped up in response to a study in which investigators at the University of York, England, measured levels of various tobacco-specific nitrosamines, N-nitrosamines, and nicotine in house dust samples from the homes of smokers.
However, even naturally occurring nitrates can be converted in the body to nitrosamines.
The HPLC chromatograms revealed the clear separation of five of the nitrosamines at their respective retention times.
Excessive amounts of nitrates in water can have lethal effects because of metahemoglobin formation in infants, and nitrosamines (carcinogenic) formation, due to a reaction between the nitrates with amines and amino acids, in adults (5).
In conventionally cured processed meats, the addition of nitrite is strictly controlled by regulations designed to minimize nitrosamine formation and maximize protection against botulism.
Our study shows that when this residual nicotine reacts with ambient nitrous acid it forms carcinogenic tobacco-specific nitrosamines or TSNAs," said Hugo Destaillats, a chemist with the Indoor Environment Department of Berkeley Lab's Environmental Energy Technologies Division.
Experiments at Lawrence Berkeley National Laboratory in California, US, showed nicotine combines with nitrous acid in the air to produce highly carcinogenic chemicals called tobacco-specific nitrosamines (TSNAs).
They found strong parallels between age-adjusted increases in death rates from Alzheimer's, Parkinson's, and diabetes, and the progressive increases in human exposure to nitrates, nitrites, and nitrosamines through the use of processed and preserved foods as well as fertilizers.
It is engaged in the development of dissolvable smokeless tobacco products that deliver fewer carcinogenic toxins (principally tobacco specific nitrosamines, or TSNAs), through the utilization of the innovative StarCured tobacco curing technology, and in sublicensing that technology to others.
Nitrosamines are among the most toxic and carcinogenic chemical compounds known.