nitric oxide 2

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nitric oxide (NO)²,

a respiratory inhalant.

indications It is used in combination with other agents and ventilatory support in the treatment of full-term and near-term (34 weeks) neonates with hypoxic respiratory failure associated with pulmonary hypertension.

contraindications Two factors that prohibit its use are dependence on right-to-left shunting of blood and known hypersensitivity.

adverse effects Life-threatening effects are pulmonary hemorrhage, intracranial hemorrhage, sepsis, stridor, methemoglobinemia, seizures, cerebral infarction, and posttreatment infection. Other adverse effects include atelectasis, hematuria, hyperglycemia, cellulitis, withdrawal syndrome, and hypotension.

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