Significance of detecting insulinlike growth factor binding protein-1 in cervicovaginal secretions: comparison with Nitrazine
test and amniotic fluid volume assessment.
The diagnosis of PPROM is made by obtaining a history of leaking amniotic fluid, clinical assessment, including speculum examination, and laboratory tests such as nitrazine
and fern tests.
CHICAGO -- The placental alpha-microglobulin-1 test is superior from a cost-benefit perspective to the combined traditional diagnostic test of pooling, nitrazine
, and ferning for screening in the setting of questionable preterm premature rupture of membranes, Dr.
The physical exam should be delayed until irrigation reaches an endpoint of neutral pH, as measured with Nitrazine
To verify the premature rupture of membranes in both groups, the speculum, fern, and nitrazine
tests were done.
I prepared the equipment I needed for the three part assessment (pooling, Nitrazine
This is important because a number of POC tests are not always recognized as "tests" by clinicians (eg, hemoccult, nitrazine
pH, provider-performed microscopy).
paper to assess the fluid collected from the posterior fornix for alkaline pH; this method has a positive predictive value (PPV) of 99% and negative predictive value (NPV) of 96%.
Fig-leaf ferning and positive nitrazine
testing: semen as a cause of misdiagnosis of premature rupture of membranes.
Nurse O'Connor performed a nitrazine
test and confirmed the presence of amniotic fluid, a sign that the patient could have had premature rupture of membranes.
Cooper's method was slightly more accurate than the 93% rate of nitrazine
strip testing, in which false positives can result from specimen contamination with urine, blood, semen, or vaginal discharges caused by infection.