nilutamide


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Related to nilutamide: Flutamide

androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

nilutamide

/ni·lu·ta·mide/ (ni-loo´tah-mīd) a nonsteroidal antiandrogen used as an antineoplastic in the treatment of prostatic carcinoma.

nilutamide

an antineoplastic hormone.
indications It is used to treat stage D2 metastatic prostatic carcinoma in combination with surgical castration.
contraindications Factors that prohibit the use of this drug include known hypersensitivity to nilutamide, severe hepatic impairment, and severe respiratory disease.
adverse effects Hepatotoxicity and interstitial pneumonitis are life-threatening effects. Other adverse effects include hot flashes, drowsiness, insomnia, dizziness, hyperthesia, depression, decreased libido, impotence, testicular atrophy, urinary tract infection, hematuria, nocturia, gynecomastia, diarrhea, nausea, vomiting, increased liver function studies, constipation, dyspepsia, rash, sweating, alopecia, dry skin, dyspnea, upper respiratory infection, pneumonia, anemia, delayed adaption to the dark, and edema.

nilutamide

RU 23908 Oncology A nonsteroidal antiandrogen that binds irreversibly to androgen receptors Indications Metastatic androgen-responsive prostate CA; when combined with LHRH analogues, achieves a relatively complete androgen blockade, preventing fatal flare-up reactions seen in early treatment of metastatic prostate CA; it may be superior to flutamide. See Disease flare-up. Cf Flutamide.
References in periodicals archive ?
Selected members of the class of N-substituted-arylthiohydantoins, analogues of the common antiandrogen therapeutic agent nilutamide, were found to have exceptionally high relative binding affinities to the AR, similar to DHT.
Comparison of in vitro effects of the pure antiandrogens OH-flutamide, casodex, and nilutamide on androgen-sensitive parameters.