The major efferent pathways are the nigrostriatal
(SNpc projections to the striatum), the mesocorticolimbic (VTA projections to the cortical and limbic regions) and the nigro-hypothalamic (SNpc projections to the hypothalamus) pathways (63).
Relationship between the appearance of symptoms and the level of nigrostriatal
degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease.
A loss of dopamine neurons causes a reduction in the amount of dopamine travelling in the nigrostriatal
pathway from the substania nigra to the striatum (Smith et al.
In a study of rats, long term intracranial injection of CCL2 activated dopamine release in the nigrostriatal
Tipping points and endogenous determinants of nigrostriatal
degeneration by MPTP.
It is a progressive degenerative clinical syndrome of the central nervous system that causes movement disorders due to dopamine deficiency in the nigrostriatal
pathway of the brain (2,3).
Inducible alterations of glutathione levels in aduit dopaminergic midbrain deurons results in nigrostriatal
It is suggested that the ability to create NMS by neuroleptics is associated with their ability to block dopamine in the nigrostriatal
pathway, mesocortical pathway, and hypothalamic nucleus.
Metformin Prevents Nigrostriatal
Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons.
2,4,7,8) In PSP, there is an increase ratio of 4 repeat tau/3 repeat tau, which affect the nigrostriatal
dopaminergic pathway, cerebral cortex cholinergic pathway and serotonergic receptors as well as the striatum and globus pallidus interna's GABAergic function.
dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.
Effects of glial cell line-derived neurotrophic factor on the nigrostriatal
dopamine system in rodents and nonhuman primates.