It is a member of matrix metalloproteinase (MMP) family in the ECM which breaks substrates such as aggrecan, versican, brevican, nidogen
, and procollagen.
ECM consists of type IV collagen, laminin, heparan sulfate proteoglycan, nidogen
, and fibronectin (Nakajima et al.
This membrane is comprised of native human amnion and chorion consisting of collagen types I, III, IV, V and VI, Laminin, Fibronectin, Nidogen
, Proteoglycans and endogenous proteins and peptides.
34 Abbreviations: BBX, bobby sox homolog (Drosophila); WDPCP, WD repeat containing planar cell polarity effector; PITRM1, pitrilysin metallopeptidase 1; RPL6P18, ribosomal protein L6 pseudogene 18; SNEDI, sushi, nidogen
and EGF-like domains 1; SORCS, sortilin- related VPStQ domain containing receptor3; TAf2Gf.
Takagi J, Yang Y, Liu JH, Wang JH, Springer TA: Complex between nidogen
and laminin fragments reveals a paradigmatic beta-propeller interface.
Uptake and degradation in vivo and in vitro of laminin and nidogen
by rat liver cells.
For cell--cell interaction genes and genes involved in signal transduction, marked increases occurred in annexin A2 (48-fold), nidogen
1 (50-fold), E-cadherin (11-fold), and [beta]-catenin (7-fold) in arsenic-induced HCC.