nicotine polacrilex

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 [nik´o-tēn, nik´o-tin]
a very poisonous alkaloid that in its pure state is a colorless, pungent, oily liquid, having an acrid burning taste. It is a constituent of tobacco, and is also produced synthetically. It is administered orally, intranasally, or by inhalation as an aid to smoking cessation. In water solution, it is sometimes used as an insecticide and plant spray.

Although nicotine is highly toxic, the amount inhaled while smoking tobacco is too small to cause death. The nicotine in tobacco can, however, cause indigestion and increase in blood pressure, and dull the appetite. It also acts as a vasoconstrictor. Researchers link smoking with heart disease, lung cancer, and other diseases.
nicotine poisoning poisoning by nicotine, such as in children who eat cigarettes, workers who handle wet tobacco leaves, or persons who overuse nicotine gums or patches. Symptoms include stimulation followed by depression of the central and autonomic nervous systems and occasionally death due to respiratory paralysis. Called also nicotinism.
nicotine polacrilex nicotine bound to a cation exchange resin; used in nicotine chewing gum as an aid to smoking cessation.

nicotine polacrilex

a chewing gum (nicotine resin complex) source of nicotine as an adjunct for smoking cessation.
indication It may be prescribed as an aid for patients who are trying to quit cigarette smoking.
contraindications Use by postmyocardial infarction patients or those with severe or worsening angina pectoris or life-threatening arrhythmias is prohibited. It should be used cautiously in patients with hyperthyroidism, hypertension, type 1 diabetes mellitus, or peptic ulcers. Drug dosages may have to be adjusted in patients taking other drugs with effects that may be increased or decreased when cigarette smoking ceases. Patients should be monitored to ensure that they do not become dependent on the nicotine in the gum.
adverse reactions The most serious adverse effects include burning and soreness of the mouth, lightheadedness, headache, hiccups, nausea, vomiting, and excessive salivation.

nic·o·tine pol·a·cri·lex

(nikō-tēn polă-krilex)
Active ingredient in nicotine gum to help people stop smoking.
References in periodicals archive ?
Although any nicotine usage during pregnancy can have detrimental effects on the fetus, the use of transdermal replacement therapy or nicotine polacrilex may be less harmful to the fetus than a mother's continued cigarette smoking.
He received bupropion SR, 150 mg bid; NRT patch, 21 mg/d; and nicotine polacrilex gum, up to 18 mg/d as needed, and tolerated the regimen well.
Effectiveness of the 4-mg dose of nicotine polacrilex for the initial treatment of high-dependent smokers.
Healthcare supplier The Perrigo Company (Nasdaq:PRGO) revealed on Thursday the receipt of approval from the US Food and Drug Administration (FDA) to market its over-the-counter coated nicotine polacrilex gum USP, 2 mg and 4 mg cinnamon flavor.
There have been no studies on the use of nicotine polacrilex chewing gum as an adjunct to cessation.