nicotine polacrilex

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 [nik´o-tēn, nik´o-tin]
a very poisonous alkaloid that in its pure state is a colorless, pungent, oily liquid, having an acrid burning taste. It is a constituent of tobacco, and is also produced synthetically. It is administered orally, intranasally, or by inhalation as an aid to smoking cessation. In water solution, it is sometimes used as an insecticide and plant spray.

Although nicotine is highly toxic, the amount inhaled while smoking tobacco is too small to cause death. The nicotine in tobacco can, however, cause indigestion and increase in blood pressure, and dull the appetite. It also acts as a vasoconstrictor. Researchers link smoking with heart disease, lung cancer, and other diseases.
nicotine poisoning poisoning by nicotine, such as in children who eat cigarettes, workers who handle wet tobacco leaves, or persons who overuse nicotine gums or patches. Symptoms include stimulation followed by depression of the central and autonomic nervous systems and occasionally death due to respiratory paralysis. Called also nicotinism.
nicotine polacrilex nicotine bound to a cation exchange resin; used in nicotine chewing gum as an aid to smoking cessation.

nicotine polacrilex

a chewing gum (nicotine resin complex) source of nicotine as an adjunct for smoking cessation.
indication It may be prescribed as an aid for patients who are trying to quit cigarette smoking.
contraindications Use by postmyocardial infarction patients or those with severe or worsening angina pectoris or life-threatening arrhythmias is prohibited. It should be used cautiously in patients with hyperthyroidism, hypertension, type 1 diabetes mellitus, or peptic ulcers. Drug dosages may have to be adjusted in patients taking other drugs with effects that may be increased or decreased when cigarette smoking ceases. Patients should be monitored to ensure that they do not become dependent on the nicotine in the gum.
adverse reactions The most serious adverse effects include burning and soreness of the mouth, lightheadedness, headache, hiccups, nausea, vomiting, and excessive salivation.

nic·o·tine pol·a·cri·lex

(nikō-tēn polă-krilex)
Active ingredient in nicotine gum to help people stop smoking.
References in periodicals archive ?
Nicotine Polacrilex Gum coated fruit and cinnamon flavors are the generic equivalent of GlaxoSmithKline Consumer Healthcare's Nicorette Fruit Chill(R) and Cinnamon Surge(TM) Coated gums, which are used as an aid to smoking cessation.
The efficacy of computer-tailored smoking cessation material as a supplement to nicotine polacrilex gum therapy.
The FDA determined that Perrigo's nicotine polacrilex gum USP, 2 mg and 4 mg dosage, in regular, orange and mint flavors, to be bioequivalent to GlaxoSmithKline's Nicorette(R) gum, indicated as an aid to smoking cessation.
a leading specialty pharmaceutical company, announced today that it has received approval from the United States Food and Drug Administration (FDA) on its Abbreviated New Drug Application (ANDA) for nicotine polacrilex gum, mint flavor, in the 2 and 4 mg strengths.
a leading specialty pharmaceutical company, announced today that it has entered into an agreement with Novartis Consumer Health, whereby, on Watson's behalf, Novartis will promote Watson's nicotine polacrilex gum, 2mg and 4mg, to specified retail outlets to which Watson does not currently promote.