nicotinamide adenine dinucleotide phosphate


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nic·o·tin·a·mide ad·e·nine di·nu·cle·o·tide phos·phate (NADP, NADP+, NADPH),

(nik'ō-tin'ă-mīd ad'ĕ-nīn dī-nū'klē-ō-tīd fos'fāt),
A coenzyme of many oxidases (dehydrogenases), in which the reaction NADP+ + 2H ⇋ NADPH + H+ takes place; the third phosphoric group esterifies the 2'-hydroxyl of the adenosine moiety of NAD+.

nic·o·tin·a·mide ad·e·nine di·nu·cle·o·tide phos·phate

(NADP) (nik'ō-tin'ă-mīd ad'ĕ-nēn dī-nū'klē-ō-tīd fos'fāt)
A coenzyme of many oxidases (dehydrogenases), in which the reaction NADP+ + 2H → NADPH + H+ takes place; the third phosphoric group esterifies the 2'-hydroxyl of the adenosine moiety of NAD.

nicotinamide adenine dinucleotide phosphate

Abbreviation: NADP
A coenzyme that contains adenosine, nicotinamide, and phosphoric acid. When in its oxidized form (NADP+), it serves as an electron carrier in catabolic and anabolic reactions. In its reduced form (NADPH or NADPH-diaphorase), it is important in reducing the ferric iron (Fe+++) to its ferrous (Fe++) form, thus converting methemoglobin (which is unable to transport oxygen) to hemoglobin (which can transport oxygen). Deficiency of NADPH-diaphorase causes congenital methemoglobinemia.
Synonym: methemoglobin reductase
See also: nicotinamide
References in periodicals archive ?
However, TCB exhibited estrogenic activity after incubation with liver microsomes of phenobarbital-treated rats in the presence of reduced nicotinamide adenine dinucleotide phosphate (NADPH).
Superoxide anion production secondary to the assembly of the PMN nicotinamide adenine dinucleotide phosphate (reduced form; NADPH) oxidase is a standard measure of PMN activation.
G6PD catalyses nicotinamide adenine dinucleotide phosphate (NADP) to its reduced form NADPH.

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