Nicastrin acts as a substrate recognition component of GS at the membrane .
In colon cancer, treatment with several chemotherapeutic agents (irinotecan, 5-FU and oxaliplatin) induces Notch1-ICD overexpression by elevating enzymic activity of GS through enhanced expression of presenilin and nicastrin.
Nicastrin is deemed the gatekeeper of the enzyme .
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
Using cultured human cells, as well as test-tube assays, university researchers singled out how just one portion of the enzyme, a protein called nicastrin, is involved in the pathway that produces beta-amyloid, thereby leading to Alzheimer's disease.
Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane.
Yu and his colleagues discovered that nicastrin binds to several proteins lodged in the cell's membrane, including one called amyloid precursor protein, or APP.
For instance, it may be possible to generate chemical compounds that specifically prevent nicastrin from latching on to APP.