neutralization

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neu·tral·i·za·tion

(nū'trăl-i-zā'shŭn),
1. The change in reaction of a solution from acid or alkaline to neutral by the addition of just a sufficient amount of an alkaline or of an acid substance, respectively.
2. The rendering ineffective of any action, process, or potential.

neutralization

[-īzā′shən]
Etymology: L, neutralis + Gk, izein, to cause
the interaction between an acid and a base that produces a solution that is neither acidic nor basic. The usual products of neutralization are a salt and water. neutralize, v.

neu·tral·i·za·tion

(nū'trăl-ī-zā'shŭn)
1. The change in reaction of a solution from acid or alkaline to neutral by the addition of just a sufficient amount of an alkaline or an acid substance, respectively.
2. The rendering ineffective of any action, process, or potential.
Synonym(s): neutralisation.

neutralization

1. A technique for determining the power of an ophthalmic lens. It is accomplished by placing a lens of known power and opposite sign in contact with the unknown lens and moved back and forth in a plane perpendicular to the line of sight until the observation of movement (against or with) of the distant image seen through the lenses disappear. The unknown lens will have the opposite power to that which neutralizes this apparent movement. 2. A method of breaking down hydrogen peroxide from a contact lens (mostly soft) following contact lens disinfection to avoid possible irritation to ocular tissues. This can be achieved by rinsing and dilution with saline, by using a solution with an enzyme catalase or a platinum disc incorporated into the lens case, or with a chemical agent such as sodium pyruvate or sodium thiosulfate. See disinfection; focimeter.

neu·tral·i·za·tion

(nū'trăl-ī-zā'shŭn)
1. The change in reaction of a solution from acid or alkaline to neutral by the addition of a sufficient amount of an alkaline or an acid substance, respectively.
2. The rendering ineffective of any action, process, or potential.
Synonym(s): neutralisation.

neutralization,

n the reaction of an acid with a base.

neutralization

the state of having been converted to neutrality from acid or base. Used also in microbiology to indicate neutralization of a toxin or of infectivity.

neutralization tests
tests based on the ability of an antibody to neutralize the biological activity of an antigen. These may utilize antitoxins and toxins or immune serum and viruses or bacteria. The tests are often quantitative whereby antibody (serum) is serially diluted; the reciprocal of the highest dilution of serum neutralizing a standard amount of toxin or virus or bacteria is the neutralizing antibody titer of that serum.
References in periodicals archive ?
90]]), microneutralization test, and pseudoparticle neutralization test (ppNT) as described (7,9) (online Technical Appendix).
A neutralization test is likely to be the optimal assay for assessing plasma used for therapy, but because our data indicated that the S1 ELISA correlates well with neutralization titers, the S1 ELISA might be a suitable screening test for selecting persons for plasma donation.
Our results suggest that the classical flavivirus plaque/focus reduction neutralization test might be reliable for determining previous Zika virus infection, particularly in the setting of retrospective serologic surveys and vaccine trials.
To ensure that diagnostic criteria of acute infection were met, as previously described, IgM-positive samples were confirmed with IgG IFA testing (5) and studied with INKV prototype strain KN3641 (1), CHATV Mohko strain M07-1 (13), and TAHV prototype strain Bardos 92 (28) plaque-reduction neutralization test (PRNT) (13).
000 RFU as saturation signal; VNT, virus neutralization test (highest neutralizing serum dilution indicated); NT, not tested; --, negative.
Characterization of DOBV hantavirus in a patient's serum by focus reduction neutralization tests, Istanbul, Turkey, 2010 * Puumala Hantaan DOBV-Aa DOBV-Af hantavirus virus (strain SK) (strain Slo) 5 <1:40 <1:40 1:640 1:1,280 26 <1:40 <1:40 1:160 1:320 * DOBV, Dobrava-Belgrade virus; Aa, Apodemus agrarius; Af, Apodemus flavicollis; SK, strain Slovakia; Slo, strain Slovenia.
ELISA+ ELISA+t Megachiroptera Cynopterus sphinx 2/2 0/3 Rousettus leschenaulti 18/20 2J/31 Total 20/22 2/34 Microchiroptera Chaerephon plicata Hipposideros armiger Hipposideros cineraceus Hipposideros larvatus Hipposideros pomona Hypsugo cadornae Megaderma spasma Miniopterus magnater Scotophilus kuhi Unidentified Total * +, positive; WB, Western blot; NT, neutralization test.
These conclusions were supported by virus neutralization test results.
Screening of pig sera for antibodies to Japanese encephalitis virus using a dot enzyme immunoassay and IgM capture ELISA: comparison with the hemagglutination inhibition and plaque reduction neutralization tests.
Focus-reduction neutralization tests (FRNTs) were performed by using the D1.
Virus neutralization tests were conducted with live NiV and HeV under Biosaftey Level 4 containment in Australia.
Thirty-nine samples (2 samples had insufficient amounts of plasma remaining) were analyzed by using NiV and HeV serum neutralization tests (SNTs) under Biosafety Level 4 conditions (10).