neurosyphilis

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neurosyphilis

 [noor″o-sif´ĭ-lis]
the central nervous system manifestations of tertiary syphilis, which may be divided into two groups, asymptomatic and symptomatic; see also general paresis and tabes dorsalis.

neu·ro·syph·i·lis

(nū'rō-sif'i-lis),
Infection of the central nervous system by Treponema pallidum (syphilis); there are several subdivisions, including asymptomatic neurosyphilis, meningeal neurosyphilis, meningovascular neurosyphilis, paretic neurosyphilis, and tabetic neurosyphilis.

neurosyphilis

/neu·ro·syph·i·lis/ (-sif´il-is) syphilis of the central nervous system.

neurosyphilis

[-sif′ilis]
Etymology: Gk, neuron + sys, hog, philein, to love
infection of the central nervous system by Treponema pallidum, the causative agent of syphilis, which may invade the meninges and cerebrovascular system. If the brain tissue is affected, general paresis may result. If the spinal cord is infected, tabes dorsalis may result. See also syphilis. neurosyphilitic, adj.

neurosyphilis

Any of the rare neurological manifestations of tertiary syphilis.

Clinical findings
Lightning-like pain, ataxia, optic nerve degeneration leading to blindness, urinary incontinence, loss of position sense, neuropathic arthropathy (Charcot joints), personality changes, aphasia, paralysis, seizures. Patients with early syphilis who are co-infected with HIV may not respond to high-dose penicillin G, leading to an increase in Tertiary syphilis.

Clinical forms of neurosyphilis
• Asymptomatic with only a positive VDRL in the CSF.
• General paresis or chronic meningoencephalitis.
• Gummatous.
• Meningovascular or thromboembolic with cerebral infarction or cranial nerve defects.
• Tabes with degeneration of the posterior columns of the spinal cord and nerve roots, decreased peripheral reflexes and proprioceptive sensation, evoking Charcot’s joints.

neurosyphilis

Neurology Any of the rare neural changes of 3º syphilis Clinical Lightning-like pain, ataxia, optic nerve degeneration → blindness, urinary incontinence, loss of position sense, Charcot's joints, personality changes, aphasia, paralysis, seizures. See STS-RPR, VDRL. See Charcot's joints, Windswept cortex, Tabes dorsalis. Cf Quaternary syphilis.

neu·ro·syph·i·lis

(nūr'ō-sif'i-lis)
Infection of the central nervous system by Treponema pallidum.

neurosyphilis

Any syphilitic infection of the nervous system. This is usually a late (tertiary) manifestation of untreated SYPHILIS, but may occur in adolescence. Its effects are widespread and include TABES DORSALIS, general paralysis of the insane (general paresis or GPI), dementia and involvement of the blood vessels of the brain and the brain coverings (meningovascular syphilis).