neurosyphilis


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neurosyphilis

 [noor″o-sif´ĭ-lis]
the central nervous system manifestations of tertiary syphilis, which may be divided into two groups, asymptomatic and symptomatic; see also general paresis and tabes dorsalis.

neu·ro·syph·i·lis

(nū'rō-sif'i-lis),
Infection of the central nervous system by Treponema pallidum (syphilis); there are several subdivisions, including asymptomatic neurosyphilis, meningeal neurosyphilis, meningovascular neurosyphilis, paretic neurosyphilis, and tabetic neurosyphilis.

neurosyphilis

/neu·ro·syph·i·lis/ (-sif´il-is) syphilis of the central nervous system.

neurosyphilis

[-sif′ilis]
Etymology: Gk, neuron + sys, hog, philein, to love
infection of the central nervous system by Treponema pallidum, the causative agent of syphilis, which may invade the meninges and cerebrovascular system. If the brain tissue is affected, general paresis may result. If the spinal cord is infected, tabes dorsalis may result. See also syphilis. neurosyphilitic, adj.

neurosyphilis

Any of the rare neurological manifestations of tertiary syphilis.

Clinical findings
Lightning-like pain, ataxia, optic nerve degeneration leading to blindness, urinary incontinence, loss of position sense, neuropathic arthropathy (Charcot joints), personality changes, aphasia, paralysis, seizures. Patients with early syphilis who are co-infected with HIV may not respond to high-dose penicillin G, leading to an increase in Tertiary syphilis.

Clinical forms of neurosyphilis
• Asymptomatic with only a positive VDRL in the CSF.
• General paresis or chronic meningoencephalitis.
• Gummatous.
• Meningovascular or thromboembolic with cerebral infarction or cranial nerve defects.
• Tabes with degeneration of the posterior columns of the spinal cord and nerve roots, decreased peripheral reflexes and proprioceptive sensation, evoking Charcot’s joints.

neurosyphilis

Neurology Any of the rare neural changes of 3º syphilis Clinical Lightning-like pain, ataxia, optic nerve degeneration → blindness, urinary incontinence, loss of position sense, Charcot's joints, personality changes, aphasia, paralysis, seizures. See STS-RPR, VDRL. See Charcot's joints, Windswept cortex, Tabes dorsalis. Cf Quaternary syphilis.

neu·ro·syph·i·lis

(nūr'ō-sif'i-lis)
Infection of the central nervous system by Treponema pallidum.

neurosyphilis

Any syphilitic infection of the nervous system. This is usually a late (tertiary) manifestation of untreated SYPHILIS, but may occur in adolescence. Its effects are widespread and include TABES DORSALIS, general paralysis of the insane (general paresis or GPI), dementia and involvement of the blood vessels of the brain and the brain coverings (meningovascular syphilis).
References in periodicals archive ?
Considering the American origin of the disease, this article presents pathographies of the most eminent Anglo-American composers and jazz musicians--neurosyphilitics (MacDowell, Joplin, Jackson, Bolden, Chauvin, Razaf, Smith, Roppolo, Young, and Parker), as well as some other famous musicians who died from neurosyphilis.
sup][5] Two cases of secondary syphilis presented with generalized lymphadenopathy, and one of them also had asymptomatic neurosyphilis.
6] analysed 92 patients with neurosyphilis and 17% had presented with psychiatric symptoms, while Timmermans and Carr [7] described 51% of 161 patients having had neuropsychiatric manifestations.
He was treated with ceftriaxone for tertiary neurosyphilis, with antivirals (fosamprenavir, abacavir/lamivudine, and ritonavir) for advanced HIV infection, and with an antifungal (fluconazole).
The guideline-recommended treatment for ocular or neurosyphilis is aqueous crystalline penicillin G, 1824 million units daily, administered as 3-4 million units IV every 4 hours for 10-14 days.
The guideline-recommended treatment for ocular or neurosyphilis is aqueous crystalline penicillin G, 18-24 million units daily, administered as 3-4 million units IV every 4 hours for 10-14 days.
Serological testing revealed his serum Venereal Disease Research Laboratory (VDRL) test and Fluorescent Treponemal Antibody-Absorption (FTA-ABS) test were positive, indicating neurosyphilis.
Cerebrospinal fluid analysis was negative for neurosyphilis.
2012) The rapid plasma reagin test cannot replace the venereal disease research laboratory test for neurosyphilis diagnosis.
Patients with newly diagnosed syphilis should be referred to their physicians for evaluation and treatment; combination treatment with penicillin, erythromycin and tetracycline is the treatment of choice, the dosage and duration of treatment depending on presence or absence of neurosyphilis.
MS Mimics (Cohen & Rensel, 2000) Inflammatory Infections Metabolic Lupus erythematosus Lyme disease Vitamin B12 deficiency Sarcoidosis HTLV-1 Hypothyroidism Sjogren HIV Copper deficiency Rheumatoid arthritis Neurosyphilis Elevated zinc ADEM Transverse myelitis Behcet disease Neuromyelitis optica Inflammatory Vascular Inherited Lupus erythematosus Migraine CADISIL Sarcoidosis Antiphospholipid Cerebellar-pontine syndrome degeneration Sjogren Diabetes Leukodystrophy Rheumatoid arthritis ADEM Transverse myelitis Behcet disease Neuromyelitis optica Note.
Neurosyphilis Masquerading as an Acute Adie's Tonic Pupil: Report of a Case Case Rep.