neuronal migration disorder

neuronal migration disorder

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NMD

Any of a group of rare neurological disorders in which embryological development of the central nervous system is flawed, resulting in structural abnormalities of the brain. Developmental delays, mental retardation, movement and muscle disorders, and seizures are common consequences. Specific diseases include agyria, lissencephaly, microgyria, and porencephaly.
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SNH was initially thought to be a neuronal migration disorder characterized by nodules of neurons due to arrested migration or failure of neuroblasts to undergo apoptosis,[sup][4] but according to recent research, neuroependymal injury, rather than an intrinsic motility defect of the cell, is thought to be an important pathogenetic factor in the development of SNHs.
GMH is a neuronal migration disorder characterised by the presence of normal grey matter neurons and glial cells, which are abnormally located in clusters within areas of white matter.
Lissencephaly is a malformation of the telencephalon that occurs due to neuronal migration disorder and leads to the failure of the formation of the cerebral convolutions, which results in a smooth appearance of brain surface.
We are presenting a case of neuronal migration disorders.
The youngster has neuronal migration disorder and peri-heteropia, a complex medical condition, which is compounded by a severe form of epilepsy.
PNH is a neuronal migration disorder characterised by nodules of ectopic neurons adjacent to the lateral ventricles, owing to failed migration of neurons from the germinal zone towards the cortical plate.
Schizencephaly is the most frequent neuronal migration disorder and it develops between the third and fifth gestational months.
The high incidence of malformative and destructive lesions studied by Frater et al[5] reinforces the impression from pediatric epilepsy surgery centers that these structural changes (sometimes described as neuronal migration disorder [NMD]) most commonly account for intractable epilepsy (including infantile spasms/ West syndrome) in infants and children.
In the case reported herein, the cerebellar and brain lesions were similar, suggesting a neuronal migration disorder as the cause of both lesions, as proposed by DE LAHUNTA & GLASS (2009).
PNH is a neuronal migration disorder characterised by nodules of ectopic neurons adjacent to the lateral ventricles, due to failed migration of neurons from the germinal zone towards the cortical plate.
INTRODUCTION: Schizencephaly is a rare neuronal migration disorder with an incidence of 1.

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