neuromuscular transmission

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Related to neuromuscular transmission: neuromuscular junction

neuromuscular transmission

the mechanism whereby motor nerve impulses initiate muscle contraction. When the impulses reach the motor nerve terminal (end plate), they cause vesicles containing acetylcholine to be released, which traverse the synaptic cleft and, on reaching the postsynaptic membrane, generate muscle action potentials.


pertaining to nerve terminations in muscles.

neuromuscular blockade
deliberate paralysis of the motor end-plates; important in veterinary surgery for immobilization. It is effected by the use of competitive (non-depolarizing) agents such as d-tubocurarine, and depolarizing agents such as succinylcholine.
neuromuscular blocking agents
drugs capable of producing neuromuscular blockade (above).
neuromuscular junction
the point of junction of a nerve fiber with the muscle that it innervates. It includes an area of folded sarcolemma of the muscle fiber, and an axon terminal located in the folds and containing vesicles of the neurotransmitter acetylcholine. Called also myoneural junction.
neuromuscular junction disease
examples are tick paralysis, botulism, myasthenia gravis.
neuromuscular paralysis
paralysis caused by malfunction at the neuromuscular junction, e.g. after administration of a neuromuscular blocking agent. The paralysis may be flaccid or spastic.
phase-II neuromuscular block
alteration of the end-plate threshold to depolarization by acetylcholine following prolonged use of a depolarization agent such as succinylcholine.
neuromuscular spindle
consists of muscle fiber, afferent and efferent nerve endings and connective tissue; maintains muscle tone via stretch reflex mediated through two neurons at spinal cord level.
neuromuscular transmission
release of acetylcholine from the nerve ending and activation of the receptors in the muscle end-plate.
References in periodicals archive ?
The effects of small incremental doses of d-tubocurarine on neuromuscular transmission in anesthetized man.
Effects of the quinoline derivatives quinine, quinidine, and chloroquine on neuromuscular transmission.
The Datex Ohmeda GE Healthcare Neuromuscular Transmission Monitor-EMG was used throughout the study.
This indicated that these patients have a decreased safety margin of neuromuscular transmission even in muscles other than extraocular muscles, which showed no clinical weakness.
In theory, with the aid of a neuromuscular transmission monitor, any non-depolarising muscle relaxant given at a sufficient dose and allowing sufficient time for onset would be safe to modify an induced seizure.
Local anaesthetics impair neuromuscular transmission, which may enhance the effect of neuromuscular blocking drugs (1,2).
Objective (quantitative) neuromuscular transmission monitoring is the only means of adequately assessing RNMB (3,4).
The correlation between depression of neuromuscular transmission and serum magnesium concentration has been established to be safe at a therapeutic range of 2 to 4 mmol/l in eclampsia (10,11) and this has been extrapolated to tetanus.
Botulinum toxin type A is known to block neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals and inhibiting the release of acetylcholine.