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a fusiform end organ in skeletal muscle in which afferent and a few efferent nerve fibers terminate; it contains from 3 to 10 modified striated muscle fibers (intrafusal fibers) that are much smaller than the ordinary muscle fibers, are separated from them by a capsule that encloses the organ, and are innervated by the thin axon of a gamma motoneuron (gamma motor fiber); the sensory endings that occur on the intrafusal fibers are either annulospiral or flower-spray endings; this sensory end organ is particularly sensitive to passive stretching of the muscle in which it is enclosed.
any one of a number of small bundles of delicate muscular fibers enclosed by a capsule, in which sensory nerve fibers terminate. The spindles vary in length from 0.8 to 5 mm, accommodating as many as four large myelinated nerve fibers that pierce the capsule and lose their myelin sheaths. The nerve fibers end as naked axons encircling the intrafusal fibers with flattened expansions or ovoid disks.
neu·ro·mus·cu·lar spin·dle(nūr'ō-mŭs'kyū-lăr spin'dĕl)
A fusiform end organ in skeletal muscle in which afferent and a few efferent nerve fibers terminate; this sensory end organ is particularly sensitive to passive stretch of the muscle in which it is enclosed.
Synonym(s): muscle spindle.
Synonym(s): muscle spindle.
Kühne,Wilhelm (Willy) F., German physiologist and histologist, 1837-1900.
Kühne fiber - artificial muscle fiber used to demonstrate the contractility of protoplasm.
Kühne methylene blue - methylene blue in absolute alcohol and phenol solution.
Kühne phenomenon - when a constant current is passed through a muscle, an undulation is seen to pass from the positive to the negative pole.
Kühne plate - the endplate of a motor nerve fiber in a muscle spindle.
Kühne spindle - a fusiform end organ in skeletal muscle in which afferent and a few efferent nerve fibers terminate. Synonym(s): neuromuscular spindle
pertaining to nerve terminations in muscles.
deliberate paralysis of the motor end-plates; important in veterinary surgery for immobilization. It is effected by the use of competitive (non-depolarizing) agents such as d-tubocurarine, and depolarizing agents such as succinylcholine.
neuromuscular blocking agents
drugs capable of producing neuromuscular blockade (above).
the point of junction of a nerve fiber with the muscle that it innervates. It includes an area of folded sarcolemma of the muscle fiber, and an axon terminal located in the folds and containing vesicles of the neurotransmitter acetylcholine. Called also myoneural junction.
paralysis caused by malfunction at the neuromuscular junction, e.g. after administration of a neuromuscular blocking agent. The paralysis may be flaccid or spastic.
phase-II neuromuscular block
alteration of the end-plate threshold to depolarization by acetylcholine following prolonged use of a depolarization agent such as succinylcholine.
consists of muscle fiber, afferent and efferent nerve endings and connective tissue; maintains muscle tone via stretch reflex mediated through two neurons at spinal cord level.
release of acetylcholine from the nerve ending and activation of the receptors in the muscle end-plate.