neuromuscular blockade

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1. in pharmacology, the blocking of the effect of a neurotransmitter or hormone by a drug.
2. in histochemistry, a chemical reaction that modifies certain chemical groups and blocks a specific staining method.
adrenergic blockade selective inhibition of the response to sympathetic impulses transmitted by epinephrine or norepinephrine at alpha or beta receptor sites of an effector organ or postganglionic adrenergic neuron. See also adrenergic blocking agent.
cholinergic blockade selective inhibition of cholinergic nerve impulses at autonomic ganglionic synapses, postganglionic parasympathetic effectors, or neuromuscular junctions. See also cholinergic blocking agent.
ganglionic blockade inhibition by drugs of nerve impulse transmission at autonomic ganglionic synapses; see also ganglionic blocking agent.
narcotic blockade inhibition of the euphoric effects of narcotic drugs by the use of other drugs, such as methadone, in the treatment of addiction.
neuromuscular blockade a failure in neuromuscular transmission that can be induced pharmacologically or result from any of various disturbances at the myoneural junction. See also neuromuscular blocking agent.
sympathetic blockade block of nerve impulse transmission between a preganglionic sympathetic fiber and the ganglion cell.

neuromuscular blockade

the inhibition of a muscular contraction activated by the nervous system, possibly resulting in muscle weakness or paralysis.

neuromuscular blockade

Neurology The partial or complete inhibition of motor activity at a neuromuscular junction Etiology
1. Reduction of post-synaptic receptors–eg, myasthenia gravis;.
2. Defective acetylcholine release from storage vesicles–eg, botulism, myasthenia, or Eaton-Lambert syndrome;.
3. Competition for binding sites, either pharmacologic blockade–eg, neostigmine, edrophonium, or toxins–eg, organophosphate insecticides. See Neuromuscular junction.

neu·ro·mus·cu·lar block·ade

(nūr'ō-mŭs'kyū-lăr blok-ād')
The blockage of transmission through the myoneural junction at nicotinic receptors, decreasing skeletal muscle tone and resulting in muscle weakness and/or paralysis.


pertaining to nerve terminations in muscles.

neuromuscular blockade
deliberate paralysis of the motor end-plates; important in veterinary surgery for immobilization. It is effected by the use of competitive (non-depolarizing) agents such as d-tubocurarine, and depolarizing agents such as succinylcholine.
neuromuscular blocking agents
drugs capable of producing neuromuscular blockade (above).
neuromuscular junction
the point of junction of a nerve fiber with the muscle that it innervates. It includes an area of folded sarcolemma of the muscle fiber, and an axon terminal located in the folds and containing vesicles of the neurotransmitter acetylcholine. Called also myoneural junction.
neuromuscular junction disease
examples are tick paralysis, botulism, myasthenia gravis.
neuromuscular paralysis
paralysis caused by malfunction at the neuromuscular junction, e.g. after administration of a neuromuscular blocking agent. The paralysis may be flaccid or spastic.
phase-II neuromuscular block
alteration of the end-plate threshold to depolarization by acetylcholine following prolonged use of a depolarization agent such as succinylcholine.
neuromuscular spindle
consists of muscle fiber, afferent and efferent nerve endings and connective tissue; maintains muscle tone via stretch reflex mediated through two neurons at spinal cord level.
neuromuscular transmission
release of acetylcholine from the nerve ending and activation of the receptors in the muscle end-plate.
References in periodicals archive ?
Hypothermic cardiopulmonary bypass and neuromuscular blockade by pancuronium and vecuronium.
Importantly, this put the testing of PTC into tactile assessment of PTC and introduced PTC into routine clinical practice for assessment of intense neuromuscular blockade.
These results demonstrate the efficacy of sugammadex in rapidly reversing profound rocuronium-induced neuromuscular blockade, an option that is not possible with conventional reversal agents," said Robert J.
The definition of residual neuromuscular blockade is a train-of-four ratio (TOF) of <0.
Similarly, this would be true if a neuromuscular blockade is in use.
Sugammadex has shown a rapid and complete reversal in this pivotal trial without evidence of PORC or re-occurrence of neuromuscular blockade.
BIS monitoring may be especially useful during neuromuscular blockade, mechanical ventilation, barbiturate coma, and bedside procedures.
The initial custom compounding service covers five drug classes - antibiotics (including Cefazolin), sedatives, neuromuscular blockade agents, narcotics, and vasopressors, said Rich Kruzynski, R.
Current parameters include EEG (also featuring Auditory Evoked Potential monitoring), neuromuscular transmission (NMT) for monitoring of neuromuscular blockade as well as electromyogram (EMG) and electrocardiogram (ECG) derivatives for monitoring of analgesia.
This study is part of a series investigating different aspects of residual neuromuscular blockade (RNMB) and neuromuscular function monitoring (NMFM).
In clinical trials to date, sugammadex has demonstrated the ability to rapidly reverse shallow and profound depths of rocuronium-induced neuromuscular blockade (NMB), thereby enabling control of the onset and offset of skeletal muscle relaxation through the use of both drugs.
Optimum bolus dose of propofol for tracheal intubation during sevoflurane induction without neuromuscular blockade in children.