neurokinin-1 antagonist

neurokinin-1 antagonist (NK1),

agent that blocks the action of substance Pm which is a peptide found in the brain and GI tract, which initiates its actions by binding to the neurokinin-1 receptor. Antagonists of the neurokinin-1 receptor have been shown to have antiemetic activity.
See also: substance P.
References in periodicals archive ?
Comparison of the neurokinin-1 antagonist GR205171, alone and in combination with the 5-HT3 antagonist ondansetron, hyoscine and placebo in the prevention of motion-induced nausea in man.