neurofilament


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Related to neurofilament: Glial fibrillary acidic protein, Neurofibrils

neurofilament

 [noor″o-fil´ah-ment]
any of the slender, fibrillar elements which, along with the neurotubules, forms a neurofibril.

neu·ro·fil·a·ment

(nū'rō-fil'ă-ment),
A class of intermediate filaments found in neurons.

neurofilament

/neu·ro·fil·a·ment/ (-fil´ah-ment) an intermediate filament occurring with neurotubules in the neurons and having cytoskeletal, and perhaps transport, functions.

neurofilament

(no͝or′ə-fĭl′ə-mənt, nyo͝or′-)
n.
Any of the long, fine threads that make up a neurofibril.

neu′ro·fil′a·men′tous (-mĕn′təs) adj.

neurofilament

[noo͡r′ōfil′əment]
Etymology: Gk, neuron, nerve + L, filare, to spin
a cytoplasmic filament approximately 10 nm in diameter occurring in the neurons. It has a cytoskeletal function and may be involved in the intracellular transport of metabolites.

neu·ro·fil·a·ment

(nūr'ō-fil'ă-mĕnt)
A class of intermediate filaments found in neurons.

neurofilament

any of the slender, fibrillar elements which, along with the neurotubules, forms a neurofibril.
References in periodicals archive ?
The expression pattern of neurofilament peptides and the presence of truncated NF on blots with no specific association to PMI delay indicate early susceptibility of this neuro-axonal intermediate filament to phosphatases and proteases and post-translational modifications.
If neurofilament blockades play an integral part in the ALS story, how might researchers prevent them from forming?
Neurofilament was present, predominately at the edge of the tumor, suggesting a relatively wellcircumscribed tumor.
Neurofilament protein antibody stained almost all cases of neurofibromas (48 of 49; 98%), with occasional cytoplasmic positivity in both nerve twiglike areas and random, single cells; about half of the cases of neurotized melanocytic nevi (25 of 49; 51%) showed occasional cytoplasmic positive staining within random tumor cells.
The peptide composition of Al-induced tangles is chiefly neurofilament protein whereas AD paired helical filaments are composed primarily of hyperphosphorylated tau (a microtubule associated protein) and ubiquitin (12,38,52).
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The ganglion cells stain positively with synaptophysin, neurofilament protein, and neuron-specific enolase.
Inhibition of neurite outgrowth in N2a cells by leptophos and carbaryl: effects on neurofilament heavy chain, GAP-43 and HSP-70.
The nature of the myelinated nerve fascicles was well demonstrated by trichrome (figure 2, E) and Bielschowsky's staining (figure 2, F), as well as by immunohistochemical staining for neurofilament protein (figure 2, G).
10,15] The resulting changes lead to swelling of axons and evolving damage to brain structures, most likely the neurofilament.
Bob Brown she looked for neurofilament mutations in familial and sporadic ALS patients.
10) Merkel cell carcinoma is believed to be derived from Merkel cells, since they both possess dense core neuroendocrine granules, neurofilament, and CK20 expression.