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neurofibrillary tangle

   Also found in: Encyclopedia, Wikipedia 0.01 sec.
Neurofibrillary tangle
—Twisted masses of protein inside nerve cells that develop in the brains of people with AD.
Mentioned in: Alzheimer's Disease

neurofibrillary tangle
Neuropathology A characteristic histologic finding in the perikaryon of large cortical neurons of Pts with Alzheimer's disease, the number of NFTs loosely correlates with the severity of dementia DiffDx Down's syndrome, subacute sclerosing panencephalitis, lead encephalopathy, tuberous sclerosis, Hallervorden-Spatz disease, lipofuscinosis, post-encephalitic parkinsonism, and normal adults–confined to the hippocampus. Cf Alzheimer's disease, Amyloid plaque, Granulovacuolar degeneration, Paired helical filaments, Senile plaques.


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