First, the release of norepinephrine can be inhibited by the level of 5-HT at the sympathetic neuroeffector
junction in blood vessels through the interactions with the presynaptic inhibitory 5-HT receptor.
Exposure to organophosphate compounds will, therefore, interfere with synaptic transmission peripherally at muscarinic neuroeffector
junctions and nicotinic receptors within sympathetic ganglia and at skeletal myoneural junctions.
The toxic effects of malathion are related to its CYP-mediated oxidative desulfuration to bioactive malaoxon leading to accretion of acetylcholine in neuroeffector
Although a number of other neurotransmitters, including acetylcholine, catecholamines, serotonin, and numerous peptides, have previously been reported to play a role in hydra's neuroeffector
systems (see Kass-Simon and Pierobon, 2007, for a review), recent studies have presented extensive evidence for the involvement of the amino acid transmitters glutamate.
describes the properties and mechanisms of drugs acting at synaptic and neuroeffector
junctional sites, on the central nervous system and inflammation, and affecting renal, cardiovascular, and gastrointestinal function.
Excess acetylcholine at neuroeffector
(muscarinic) myoneural junctions and autonomic ganglia (nicotinic) produces such symptoms as bradycardia, bronchorrhea, lacrimation, salivation, emesis, diarrhea, diaphoresis, fasciculation, and muscle paralysis.