neuritic plaque


Also found in: Encyclopedia.

neu·rit·ic plaque

a spheric mass primarily composed of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.

neuritic plaque

[noo͡rit′ik]
an extracellular deposit consisting of beta-amyloid protein mixed with branches of dying nerve cells in the brain of a patient with Alzheimer's disease.

senile plaque

A histologic finding consisting of a core of extracellular amyloid with an amyloidogenic fragment (betaA4) derived from amyloid precursor protein, surrounded by a tangled spherical mass of argyrophilic cholinergic neuritis (axons/dendrites) seen in the grey matter (neocortex, hippocampus, amygdala, less commonly, basal ganglia and elsewhere) in the brains of older persons, but markedly increased in Alzheimer’s disease.

se·nile plaque

(sen'il plak)
A spheric mass composed primarily of amyloid fibrils and interwoven neuronal processes, frequently, although not exclusively, observed in Alzheimer disease.
Synonym(s): neuritic plaque.
References in periodicals archive ?
PART is characterized by NFT pathology in structures of the mesial temporal lobe, basal forebrain, and brainstem (Braak stages < IV) with minimal or no A[beta] or neocortical neuritic plaque pathologies.
Food and Drug Administration (FDA) approved VIZAMYL for PET imaging of the brain to estimate beta amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for AD or other causes of cognitive decline.
18) Additionally, PiB binds to both diffuse and neuritic plaques, which may affect the in vivo signal.
8] Neurofibrillary tangles and neuritic plaques, the hallmarks of AD, can also be found in other neurodegenerative disorders, as well as in cognitively intact elderly.
As early as the 1920s, the neuropathological characteristics -- particularly nerve cell loss and the appearance of abnormal cell lesions called neurofibrillary tangles and neuritic plaques -- were observed in the brains of Down's individuals over 35 years of age.
However, our observation of an elevated e4 frequency in the [pure Lewy body] and [Parkinson's dementia] groups in which the overall brain neuritic plaque burden is low suggests the possibility that ApoE isoforms also might modulate neurodegeneration by nonamyloidogenic mechanisms, they pointed out.
Pharmaceutical products company Eli Lilly and Company (NYSE:LLY) and its wholly owned subsidiary Avid Radiopharmaceuticals Inc announced on Friday the receipt of a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in Europe, recommending approval of Amyvid (Florbetapir F 18) solution for injection as a diagnostic radiopharmaceutical indicated for Positron Emission Tomography (PET) imaging of beta-amyloid neuritic plaque density.
Food and Drug Administration (FDA) approval of Vizamyl (Flutemetamol F18 injection), a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate beta amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer s disease (AD) or other causes of cognitive decline.
Eli Lilly and Company (NYSE: LLY) and its wholly owned subsidiary Avid Radiopharmaceuticals Inc announced on 19 October that they have received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) in Europe recommending approval of Amyvid solution for injection as a diagnostic radiopharmaceutical indicated for Positron Emission Tomography imaging of beta-amyloid neuritic plaque density in the brains of adult patients with cognitive impairment, who are being evaluated for Alzheimer's Disease and other causes of cognitive impairment.
According to the company, Amyvid (Florbetapir F-18 Injection) is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate beta-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline.
The results of this study suggest that combination of insulin with other diabetes medication is associated with a substantial reduction in brain neuritic plaque density consistent with the effects of both on the neurobiology of insulin," Dr.
These findings were demonstrated on a background of multifocal cerebral hemorrhage, as evidenced by hemosiderin laden macrophages seen in figure 7 (arrow), as well as neurofibrillary tangles and neuritic plaques characteristic of Alzhemer's disease.