neuraminidase inhibitors

neuraminidase inhibitors

Drugs used to treat INFLUENZA, that interfere with the release of progeny influenza virus from infected host cells. They must be used as early in the illness as possible because replication of influenza viruses is maximal within 24 to 72 hours after onset. Examples are oseltamivir (Tamiflu) and zanamivir (Relenza).
References in periodicals archive ?
Other reactions included a risk of neuropsychiatric events such as confusion or delirium, as well as serious skin reactions, although these are similar reactions to other neuraminidase inhibitors.
Hoffmann-La Roche (Roche) (Indianapolis, IN, USA), is the market leader of the neuraminidase inhibitors (NAI), the first class of antiviral drugs designed specifically to treat influenza.
Buhner names 14 plants, including Chinese skullcap, licorice, elder, ginger, and rhodiola, that are also neuraminidase inhibitors.
Both M2-ion channel blockers, such as amantadine, and neuraminidase inhibitors, such as Tamiflu or Relenza, are used as antiviral drugs for influenza infections of humans," Richt said.
If started promptly, antiviral medications may reduce complications of acute influenza, but increasing resistance to amantadine and perhaps neuraminidase inhibitors underscores the need for novel prevention and treatment strategies.
Worldwide, approved drugs for the treatment of influenza are the adamantanes amantadine and rimantadine and the neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, and peramivir.
3-6] In September 2009 Jefferson asked Roche for the unpublished data set that Roche used in an analysis published in 2003, for use the following month to update the Cochrane Collaboration's review on neuraminidase inhibitors in healthy adults.
Widespread Use of Neuraminidase Inhibitors in Japan, and Several Issues to be Resolved.
Among their perspectives are inhibiting HIV entry, helicase-primase inhibitors as a new approach to combating herpes simplex virus and varicella zoster virus, alkoxyalkyl ester pro-drugs of antiviral nucleoside phosphate and phosphonates, maribavir as a novel benzimidazole ribonucleoside for preventing and treating cytomegalovirus diseases, lethal mutagenesis as an unconventional approach to combating HIV, silencing viruses with antiviral RNAi, and neuraminidase inhibitors as anti-influenza agents.
Once the 2009 HIN1 pandemic ended, "it may be that clinicians do not prescribe neuraminidase inhibitors as aggressively as the CDC recommendations would support," he said.
Importantly, it has no cross-resistance with the neuraminidase inhibitors or adamantanes.
Combo therapy with neuraminidase inhibitors, ribavirin, adamantanes, and interferon was widely used for avian influenza A(H5N1), but due to the lack of controls it's hard to draw any conclusions as to whether this resulted in enhanced efficacy.