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netilmicin

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netilmicin /net·il·mi·cin/ (net″il-mi´sin) a semisynthetic aminoglycoside antibiotic having a wide range of activity; used as the sulfate salt in the treatment of infection caused by susceptible gram-negative organisms.
aminoglycoside [ah-me″no-gli´ko-sīd]
any of a group of antibacterial antibiotics derived from species of Streptomyces; they interfere with the function of bacterial ribosomes. They contain an inositol moiety substituted with two amino or guanidino groups and with one or more sugars or aminosugars. The group includes amikacin, gentamicin, kanamycin, neomycin, streptomycin, and tobramycin. They are used to treat infections caused by gram-negative organisms and are classified as bactericidal agents because of their interference with bacterial replication. All are highly toxic, requiring frequent monitoring of blood serum levels and careful observation of the patient for early signs of toxicity, particularly ototoxicity and nephrotoxicity.

netilmicin
a semisynthetic aminoglycoside antibiotic.


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The tested antimicrobial agents were: amikacin (30 [micrón]g), ampicillin (10 [micrón]g), carbenicillin (100 [micrón]g), cefoperazone (75 [micrón]g), cefotaxime (30 [micrón]g), cefoxitin (30 [micrón]g), chloramphenicol (30 [micrón]g), trimethoprimsulfamethoxazole (25 [micrón]g), gentamicin (10 [micrón]g), neomycin (30 [micrón]g), netilmicin (30 [micrón]g), polymyxin B (300 [micrón]g), tetracycline (30 [micrón]g) and tobramycin (10 [micrón]g).
Susceptibility to aminoglycosides depends on the Lactobacillus species and bifunctional enzymes have been described in some strains, conferring high resistance levels to gentamicin, kanamycin, tobramycin and netilmicin.
 
 
 
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