nested variant of urothelial carcinoma
nested variant of urothelial carcinomaA rare (less than 0.3% of invasive bladder tumours), deceptively bland yet clinically aggressive urothelial carcinoma, which affects older people, especially males.
Haematuria (usually macroscopic), dysuria, frequency, nocturia. Despite NVUCs’ low-grade histology, they are bad actors which, given the typical delay in diagnosis, contributes to their more advanced local stage compared to conventional high-grade urothelial carcinoma.
The optimal treatment for NVUCs is uncertain given its rarity—radical resection is recommended; chemo- and radiotherapy are completely ineffective.
Most patients die within 3 years.