neprilysin


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nep·ri·ly·sin

(nep-rĭ-lī-sin),
A metallomembrane endopeptidase enzyme, a major constituent of kidney brush-border membranes. Also found in the brain. Identical to common acute lymphoblastic leukemic antigen.
References in periodicals archive ?
15] Entresto contains the neprilysin inhibitor sacubitril, which is a new molecular entity, and the angiotensin receptor blocker (ARB) valsartan.
the novel angiotensin receptor neprilysin inhibitor (ARNI) known as LCZ696 or valsarian/sacubitril.
Entresto exhibits the mechanism of action of an Angiotensin Receptor Neprilysin Inhibitor that reduces the strain on the failing heart.
New drug for heart failure: Angiotensin-receptor neprilysin inhibitor, or ARNI, has been fast-tracked by the FDA because of its impressive survival advantage over the ACE inhibitor enalapril, the current standard for treating patients with heart failure.
Novartis' angiotensin receptor neprilysin inhibitor (ARNi), LCZ696, for the treatment of heart failure : LCZ696 has exhibited statistically superior data to enalapril.
8 ng/ml active IDE and has minimal cross reaction with Neprilysin, TACE, b-Secretase, ADAM10 and BACE2.
CD-10, or neprilysin, is a zinc-dependent metalloprotease that plays a role in degrading the protein Endothelin-1 (ET-1).
In addition to DPP-4, neprilysin and insulin-degrading enzyme (IDE) can also remove amino-terminal residues and produce ring cleaved forms and, for IDE, carboxy-terminal deleted forms (10, 11).
Transport of A[beta] across the blood-brain barrier is mediated by receptors such as RAGE or LRP, enzymatic degradation is achieved by neprilysin and insulin-degrading enzyme, and A[beta] aggregation is prevented by anti-A[beta] antibodies and A[beta]-binding proteins.
Ginsenoside Rg3 promotes beta-amyloid peptide degradation by enhancing gene expression of neprilysin.
In vitro Pb exposure disturbs the balance between A[beta] production and elimination: the role of A[beta]PP and neprilysin.