neprilysin


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nep·ri·ly·sin

(nep-rĭ-lī-sin),
A metallomembrane endopeptidase enzyme, a major constituent of kidney brush-border membranes. Also found in the brain. Identical to common acute lymphoblastic leukemic antigen.
References in periodicals archive ?
34) Entresto is actually a combination of two drugs: valsartan, which is an angiotensin II receptor blocker, and sacubitril, which is a neprilysin inhibitor.
New classes, new agents Sacubitril, a neprilysin inhibitor, is the first drug from this class approved for use in the United States.
Canalicular immunostaining of neprilysin (CD10) as a diagnostic marker for hepatocellular carcinomas.
Effects of neprilysin expression on stromal and breast cancer cell invasion.
This is a combination of a class of drug already used to treat heart failure, valsartan (an angiotensin receptor blocker or ARB) and a new drug, sacubitril (a neprilysin inhibitor).
Moreover, the levels of A[beta]-degrading proteins, such as matrix metalloproteinase-9, insulin-degrading enzyme, neprilysin, heat shock protein-70, and lipoprotein receptor-related protein-1, increased by treadmill exercise and have been revealed to be responsible for the upregulation of A[beta] clearance (26).
This annual review brings together 33 articles in various areas of medicine: cardiac pacing and defibrillation devices, transcatheter aortic valve replacement, tissue engineering, neprilysin inhibitors as therapy for heart failure, therapeutics for thoracic aortic aneurysms and acute aortic dissections, lymphangioleiomyomatosis, nonalcoholic steatohepatitis, obstructive sleep apnea, personalized cancer therapy and next-generation sequencing technology, precision medicine in myelodysplastic syndromes and leukemias, chimeric antigen receptor (CAR) Y cell therapy for solid tumors, and therapy for non-small cell lung cancer.
The variety of such fragments is believed to be the result of proteolysis by dipeptidyl peptidase IV (DPP IV), which forms BNP 3-32 and neprilysin (NEP), which forms BNP 5-32.
Instead, it works by raising the levels of the enzyme known as neprilysin, which then degrades the plaques.
Entresto is a combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker.
11) - Pipeline Review, H1 2016', provides in depth analysis on Neprilysin (Neutral Endopeptidase 24.
Entresto contains the neprilysin inhibitor sacubitril, which is a new molecular entity, and the angiotensin receptor blocker (ARB) valsartan.