It is, however, nephrotoxic
and ototoxic, but can be administered in a single dose of 500 mg.
Exenatide is used in patients at risk for renovascular disease, and it is frequently associated with potentially nephrotoxic
drugs such as metformin, angiotensin-converting enzyme (ACE) inhibitors, ARBs, and diuretics.
Renal toxicity can be minimised by preventing volume depletion, avoiding concomitant nephrotoxic
drugs, frequent monitoring of creatinine and therapeutic drug monitoring.
Analysis of data from the tenofovir expanded-access programme revealed that being on concomitant nephrotoxic
medications was an independent risk factor for elevations in serum creatinine during follow-up.
Risk factors included in the analysis were gender, admission diagnosis, age, weight, APACHe II, pre-existing renal impairment, volume of contrast of more than 1 ml/kg, background of hypertension, diabetes, co-administration of nephrotoxic
medications, intra-arterial contrast administration, multiple studies, age, sepsis diagnosed at the time of the study, use of vasopressors and inotropes, mean arterial pressure, inspired oxygen fraction, creatinine level and urinary output.
Combination of ceftriaxone and acyclovir--an underestimated nephrotoxic
Look for a recent urinary tract infection, also for decreased blood pressure or maybe the presence of nephrotoxic
Other major causes are ischemia and nephrotoxic
In addition, many nephrotoxic
drugs are also ototoxic.
2], both of which are nephrotoxic
The rationale for using the F [kappa] and F [lambda] antisera is that they specifically detect the urinary free [kappa] and [lambda] light chains that may have nephrotoxic
The nephrotoxicity observed in the patient described in their report, (1) therefore, needs to be interpreted within the context of the higher-than-normal dose of CMS administered and the recent exposure of the patient to other potentially nephrotoxic
drugs (gentamicin, imipenem) and other events (systemic hypotension).