nephrotoxic


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Related to nephrotoxic: ototoxic, hepatotoxic, nephromalacia

nephrotoxic

 [nef´ro-tok″sik]
pertaining to or characterized by nephrotoxicity.

neph·ro·tox·ic

(nef'rō-tok'sik),
1. Pertaining to nephrotoxin; toxic to renal cells.
2. Synonym(s): nephrolytic

nephrotoxic

/neph·ro·tox·ic/ (nef´ro-tok″sik) destructive to kidney cells.

neph·ro·tox·ic

(nef'rō-tok'sik)
1. Pertaining to nephrotoxin; toxic to renal cells.
2. Synonym(s): nephrolytic.

Nephrotoxic

Toxic, or damaging, to the kidney.
Mentioned in: Acute Kidney Failure

nephrotoxic

destructive to kidney cells.

nephrotoxic nephritis
an experimental disease induced by the injection of anti-rat-kidney antibodies. Called also Masugi nephritis.
References in periodicals archive ?
It is, however, nephrotoxic and ototoxic, but can be administered in a single dose of 500 mg.
Exenatide is used in patients at risk for renovascular disease, and it is frequently associated with potentially nephrotoxic drugs such as metformin, angiotensin-converting enzyme (ACE) inhibitors, ARBs, and diuretics.
Renal toxicity can be minimised by preventing volume depletion, avoiding concomitant nephrotoxic drugs, frequent monitoring of creatinine and therapeutic drug monitoring.
Analysis of data from the tenofovir expanded-access programme revealed that being on concomitant nephrotoxic medications was an independent risk factor for elevations in serum creatinine during follow-up.
Risk factors included in the analysis were gender, admission diagnosis, age, weight, APACHe II, pre-existing renal impairment, volume of contrast of more than 1 ml/kg, background of hypertension, diabetes, co-administration of nephrotoxic medications, intra-arterial contrast administration, multiple studies, age, sepsis diagnosed at the time of the study, use of vasopressors and inotropes, mean arterial pressure, inspired oxygen fraction, creatinine level and urinary output.
Look for a recent urinary tract infection, also for decreased blood pressure or maybe the presence of nephrotoxic drugs.
Other major causes are ischemia and nephrotoxic agents.
In addition, many nephrotoxic drugs are also ototoxic.
The rationale for using the F [kappa] and F [lambda] antisera is that they specifically detect the urinary free [kappa] and [lambda] light chains that may have nephrotoxic potential (1).
The nephrotoxicity observed in the patient described in their report, (1) therefore, needs to be interpreted within the context of the higher-than-normal dose of CMS administered and the recent exposure of the patient to other potentially nephrotoxic drugs (gentamicin, imipenem) and other events (systemic hypotension).