Results: Biochemical and histopathological analysis showed significant kidney injury in rabbits exposed to acute nephrotoxic
doses of amphotericin B and cyclosporine.
5) AKI may start with problems outside the kidney that compromise organ perfusion such as low blood volume, cardiac output, or blood pressure, or be caused by direct injury of kidney nephrons associated with nephrotoxic
drugs, reactive oxygen species, inflammatory factors, or other causes.
Both amikacin and flunixin meglumine are considered nephrotoxic
in avian species, but some species are more sensitive to adverse renal effects.
Compound A has been shown to be nephrotoxic
in rats (16).
On the part of the physician, close attention to haemodynamic and volume status and avoidance of nephrotoxic
medications is important.
The steady state may be reached days after the exposure to nephrotoxic
Categorical variables including dehydration, preexisting renal disease, history of renal surgery, diabetes mellitus, hypertension, nephrotoxic
drug Intake, heart failure, previous contrast use, and the osmolarity of the contrast media were presented as counts and percentages and compared with Fisher's exact test.
This article will review our understanding of common nephrotoxic
chemotherapeutic agents, and highlight therapies with potential renal implications for a variety of targeted pathways.
2 ) because of the risk of nephrogenic systemic fibrosis, these agents are not considered to be nephrotoxic
Conclusions: This experiment proves that the herbomineral preparations (kushta) of gold which are nephrotoxic
in rats may have similar toxic effects in human beings.
Additionally, because chemotherapy may be hepatotoxic or nephrotoxic
, baseline liver and renal function tests should almost always be performed.
The nurse should document the use of current and past prescription, and over-the-counter drugs because many drugs have the potential to be nephrotoxic