nephrosis


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Related to nephrosis: hydronephrosis

nephrosis

 [nĕ-fro´sis]
2. any kidney disease, especially one marked by purely degenerative lesions of the renal tubules. adj., adj nephrot´ic. Often the cause is not known. When a viral infection precedes the symptoms, it is probably a precipitating rather than a causative factor. There may be not one but several pathologic processes involved, all of which affect the glomerular membranes, increasing their permeability to protein.

The loss of proteins, especially albumin, by leakage from the capillaries into the urine, produces a shift of fluids from the intravascular fluid compartment into the interstitial spaces. The result is edema and hypovolemia, which stimulates tubular reabsorption of sodium and water to increase intravascular volume. These pathologic processes and others that are less well understood bring about the group of symptoms known as the nephrotic syndrome.

The first sign noted is usually swelling about the eyes on rising in the morning that subsides during the day. As edema worsens there is a gradual weight gain, which parents may mistake for healthy growth. The fluid shift progresses and eventually causes abdominal swelling from ascites, respiratory difficulty from pleural effusion, and generalized edema. anasarca (severe generalized swelling) sometimes occurs in association with an acute infection. Intestinal edema can cause diarrhea and anorexia. There is also a diminished output of urine, which is dark and frothy.
Diagnosis and Treatment. Laboratory analyses of urine and blood reveal proteinuria, elevated specific gravity of the urine, decreased serum proteins, and elevated serum cholesterol levels. Renal biopsy and the appearance of renal tissue under microscopic examination can establish the diagnosis and identify the type of nephrotic syndrome present.

Treatment includes rest during the edema phase, management of fluid balance, and administration of corticosteroids such as prednisone. Corticosteroid therapy is gradually decreased until the urine is free of proteins and edema subsides. About 80 per cent of children with nephrosis have a favorable prognosis. Cases resistant to this therapy may be given an immunosuppressant such as cytoxan, which is alternated with prednisone every other day.
Patient Care. The acutely ill child is hospitalized for diagnostic testing and placed on bed rest until there is remission of symptoms. In the presence of massive edema, sodium is restricted but water usually is not. While on bed rest the child will need diligent skin care to prevent breakdown of the skin over edematous tissues. Measures are taken to avoid respiratory infections to which these children are especially susceptible.

Monitoring includes measurement of vital signs, daily weight, fluid intake and output, and abdominal girth. The progress of edema is assessed daily or more often as indicated. Once the swelling subsides the child usually is less lethargic and should be ready and eager to resume usual activities.

In preparation for discharge the parents are taught how to test urine for albumin, the purpose and untoward side effects of prescribed medications, signs of relapse, and the techniques and importance of avoiding infection. Referral to a home health care nurse or visiting nurse may be appropriate if the parents have a need for continued support and guidance.
amyloid nephrosis chronic nephrosis with amyloid degeneration of the median coat of the arteries and glomerular capillaries.
lipid nephrosis (lipoid nephrosis) minimal change disease.
lower nephron nephrosis renal insufficiency leading to uremia, due to necrosis of the lower nephron cells that blocks the tubular lumens of this region; seen after severe injuries, especially crushing injury to muscles. See also crush syndrome.

ne·phro·sis

(ne-frō'sis),
1. Synonym(s): nephropathy
2. Degeneration of renal tubular epithelium.
3. Synonym(s): nephrotic syndrome
[nephro- + G. -osis, condition]

nephrosis

/ne·phro·sis/ (nĕ-fro´sis) [Gr.] any kidney disease characterized by purely degenerative lesions of the renal tubules.
amyloid nephrosis  renal amyloidosis.
lipid nephrosis  minimal change disease.
lower nephron nephrosis  renal insufficiency leading to uremia, due to necrosis of the lower nephron cells, blocking the tubular lumens of this region; seen after severe injuries, especially crushing injury to muscles (crush syndrome) .

nephrosis

(nə-frō′sĭs)
n. pl. nephro·ses (-sēz)
A disease of the kidneys marked by degenerative lesions, especially of the winding uriniferous tubules.

ne·phrot′ic (-frŏt′ĭk) adj.

nephrosis

nephrosis

(1) Nephrotic syndrome, see there.
(2) A non-inflammatory, non-neoplastic disease of kidney, typically used with modifiers (e.g., lipoid nephrosis).

nephrosis

Nephrology
1. Nephrotic syndrome, see there. See Nil disease, Myeloma kidney. Cf Nephritis.
2. A noninflammatory, nonneoplastic disease of kidney. See Bile nephrosis, Cholemic nephrosis.

ne·phro·sis

(ne'frō'sis)
1. Synonym(s): nephropathy.
2. Degeneration of renal tubular epithelium.
3. Synonym(s): nephrotic syndrome.
[nephro- + G. -osis, condition]

nephrosis

See NEPHROTIC SYNDROME.

nephrosis

degenerative changes in the epithelium of the kidney tubules, resulting in large molucules leaving the blood plasma and being excreted in the urine.

Nephrosis

Any degenerative disease of the kidney (not to be confused with nephritis, an inflammation of the kidney due to bacteria).

nephrosis

disease characterized by purely degenerative lesions of the renal tubules.

amyloid nephrosis
chronic nephrosis with amyloid deposition in glomerular capillaries, in basement membranes of tubules and eventually around tubules.
biliary nephrosis
the renal component of acute hepatic failure characterized by oliguria and azotemia.
infectious avian nephrosis
see infectious bursal disease.
lipid nephrosis
nephrosis marked by edema, albuminuria, and changes in the protein and lipids of the blood and accumulation of globules of cholesterol esters in the tubular epithelium of the kidney.
lower nephron nephrosis
now called acute renal tubular necrosis where tubular degeneration occurs as a consequence of ischemia and nephrotoxins. Complete urinary outflow obstruction follows, resulting in acute renal failure. Also seen after severe injuries, especially crushing injury to muscles. See also crush syndrome.
mycotic nephrosis
caused by ingested toxins of Aspergillus ochraceus, Penicillium viridicatum. Characterized by enlarged, terminally fibrosed kidneys, polyuria and polydipsia. See also mycotoxicosis.
References in periodicals archive ?
Monoclonal antibodies are available against many potentially pathogenic proteins; antibodies against basic fibroblast growth factor reduce proteinuria and podocyte desmin staining in puromcyin aminonucleoside nephrosis.
A hitherto underscribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis.
Studies on antinephritic effect of TJ-8014, Syo-Saiko-To-Kyo-Shokyo-Ka-Ouren-Bukuryou (5): effect on puromycin aminonucleoside nephrosis and its mechanisms.
WARNING: Renal dysfunction, acute renal failure, osmotic nephrosis, and death may be associated with the administration of Immune Globulin Intravenous (Human) (IVIg) products in predisposed patients.
It also appears to be capable of producing acute tubular injury, leading to osmotic nephrosis and acute tubular necrosis.
1999); increased mortality from hypertensive heart disease, nephritis and nephrosis, and prostate cancer in Utah (Lewis et al.
Acute human immunodeficiency virus infection temporally associated with rhabdomyolysis, acute renal failure, and nephrosis.
Glomerular basement membrane anionic charge site changes in aminonucleoside nephrosis.
Immune Globulin Intravenous (Human) products have been reported to be associated with renal dysfunction, acute renal failure, osmotic nephrosis and death.
y/Sex Symptoms 1 76/M Hematuria 2 73/F Hematuria, flank pain 3 76/M Follow-up of bladder UC 4 73/F Follow-up of bladder UC 5 58/M Hematuria 6 74/M Hematuria, flank pain 7 54/M Flank pain 8 61/M Flank pain 9 69/M Nephrosis 10 22/M Hematuria 11 70/M Hematuria Case Tumor %of No.
1990) reported a significant increase in mortality for nephritis and nephrosis in the 1985 follow-up study of workers exposed to man-made mineral fibers.
TABLE The 10 Leading Causes of Death in the United States in 1900 and 2000 Causes of Death in 1900 Causes of Death in 2000 Pneumonia Heart disease Tuberculosis Cancer Diarrhea and enteritis Stroke Heart disease Chronic lower respiratory disease Chronic nephritis Accidents Unintentional injury Diabetes Diabetes Pneumonia/influenza Diseases of early infancy Alzheimer's disease Cancer Nephritis, nephrotic syndrome, and nephrosis Diphtheria Scpticemia Adapted from Grove and Hetzel, (1) and Minino and Smith.