Nephritic factor | definition of nephritic factor by Medical dictionary
a serum protein (possibly an IgG autoantibody), found in some patients with membranoproliferative glomerulonephritis and hypocomplementemia, which, together with the cofactors of the alternate pathway of complement activation, cleaves the third component of complement (C3).
a protein found in the serum of patients with membranoproliferative glomerulonephritis. It activates alternative complement pathways.
References in periodicals archive
However, patient 4 with DDD had a significantly increased C3 nephritic factor
that normalized after treatment.
C3 nephritic factor
and hypocompiementaemia in a clinically healthy individual.
11) Serologically, C3 nephritic factor
, an autoantibody against alternate pathway C3 convertase, is detected in the sera of patients with type-II MPGN.