nephritic factor

ne·phrit·ic fac·tor

a serum protein (possibly an IgG autoantibody), found in some patients with membranoproliferative glomerulonephritis and hypocomplementemia, which, together with the cofactors of the alternate pathway of complement activation, cleaves the third component of complement (C3).

nephritic factor

a protein found in the serum of patients with membranoproliferative glomerulonephritis. It activates alternative complement pathways.
References in periodicals archive ?
11) Serologically, C3 nephritic factor, an autoantibody against alternate pathway C3 convertase, is detected in the sera of patients with type-II MPGN.