neostigmine


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Related to neostigmine: Pyridostigmine, Edrophonium, glycopyrrolate

neostigmine

 [ne″o-stig´mēn]
an anticholinesterase and prokinetic agent used for the symptomatic treatment of myasthenia gravis, for prevention and treatment of postoperative stasis and atony of the gastrointestinal tract or urinary bladder, and for reversal of the effects of certain neuromuscular blocking agents, such as tubocurarine, after surgery. Available as neostigmine bromide and neostigmine methylsulfate.

neostigmine

/neo·stig·mine/ (-stig´mēn) a cholinergic (cholinesterase inhibitor), used as the bromide or methylsulfate salt in the treatment of myasthenia gravis, in the prevention and treatment of postoperative stasis and atony of the gastrointestinal tract or urinary bladder, and for postsurgical reversal of the effects of nondepolarizing neuromuscular blocking agents.

neostigmine

(nē′ō-stĭg′mēn, -mĭn)
n.
A cholinesterase inhibitor that is given in the form of a bromide salt, C12H19BrN2O2, or a methyl sulfate, C13H22N2O6S, used to treat myasthenia gravis and muscle atony and to reverse the effects of muscle relaxants after surgery.

neostigmine

Pharmacology An anticholinesterase used for the symptomatic therapy of myasthenia gravis and, in anesthesiology, to reverse the effects of depolarizing agents. See Myasthenia gravis, Reversal agent.

neostigmine

An ANTICHOLINESTERASE drug used in the treatment of MYASTHENIA GRAVIS. Neostigmine interferes with the enzyme that breaks down the neurotransmitter ACETYLCHOLINE and so prolongs its action. The drug is on the WHO official list. A brand name is Robinul neostigmine.

neostigmine

A reversible anticholinesterase drug, which neutralizes the effect of acetylcholinesterase and thereby allows the prolonged action of acetylcholine on the iris and ciliary muscle. Its action is similar to physostigmine but it is not so irritating a miotic. Both are occasionally used in the treatment of glaucoma. See acetylcholine; parasympathomimetic; physostigmine; miosis; miotics.

neostigmine

an anticholinesterase used in the treatment of myasthenia gravis and glaucoma and as an antidote for nondepolarizing muscle relaxants, such as tubocurarine.

neostigmine test
muscle weakness caused by myastenia gravis is temporarily reversed following the administration of neostigmine; used as a diagnostic test.
References in periodicals archive ?
All other Neostigmine Methylsulfate Injections are not FDA-approved and are subject to removal by the FDA.
The safety aspect of neostigmine in these patients would no longer be an issue if we stopped using it.
The recommended average dosing regimen for the reversal of non-depolarising neuromuscular blockade in adults is neostigmine 2.
Flow injection determination of neostigmine and galantharnine by immobilized AChE inhibition.
The Aurora trial compared the efficacy of sugammadex and neostigmine for the reversal of shallow neuromuscular blockade induced by single or multiple doses of either rocuronium (Esmeron(R)/Zemuron(R)) or vecuronium (Norcuron(R)).
Both neostigmine and atropine should be avoided in heart transplant recipients where possible.
Neostigmine is recommended in the management of mamba bites.
At the end of surgery, injection atropine and neostigmine were given to antagonize the residual effect of rocuronium4.
With one exception, which show an unexplained potentiation of neostigmine stimulated colon activity, all other studies result in effects, indicating a substantial spasmolytic effect of PO of the smooth muscles of the gastrointestinal tract.
Neostigmine and ice-pack tests were performed and each confirmed a diagnosis of myasthenia gravis (MG).
Non-depolarising muscle relaxants, when used, were reversed with neostigmine and atropine.