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an anticholinesterase and prokinetic agent used for the symptomatic treatment of myasthenia gravis, for prevention and treatment of postoperative stasis and atony of the gastrointestinal tract or urinary bladder, and for reversal of the effects of certain neuromuscular blocking agents, such as tubocurarine, after surgery. Available as neostigmine bromide and neostigmine methylsulfate.
neostigmine/neo·stig·mine/ (-stig´mēn) a cholinergic (cholinesterase inhibitor), used as the bromide or methylsulfate salt in the treatment of myasthenia gravis, in the prevention and treatment of postoperative stasis and atony of the gastrointestinal tract or urinary bladder, and for postsurgical reversal of the effects of nondepolarizing neuromuscular blocking agents.
A cholinesterase inhibitor that is given in the form of a bromide salt, C12H19BrN2O2, or a methyl sulfate, C13H22N2O6S, used to treat myasthenia gravis and muscle atony and to reverse the effects of muscle relaxants after surgery.
neostigminePharmacology An anticholinesterase used for the symptomatic therapy of myasthenia gravis and, in anesthesiology, to reverse the effects of depolarizing agents. See Myasthenia gravis, Reversal agent.
neostigmineAn ANTICHOLINESTERASE drug used in the treatment of MYASTHENIA GRAVIS. Neostigmine interferes with the enzyme that breaks down the neurotransmitter ACETYLCHOLINE and so prolongs its action. The drug is on the WHO official list. A brand name is Robinul neostigmine.
A reversible anticholinesterase drug, which neutralizes the effect of acetylcholinesterase and thereby allows the prolonged action of acetylcholine on the iris and ciliary muscle. Its action is similar to physostigmine but it is not so irritating a miotic. Both are occasionally used in the treatment of glaucoma. See acetylcholine; parasympathomimetic; physostigmine; miosis; miotics.
an anticholinesterase used in the treatment of myasthenia gravis and glaucoma and as an antidote for nondepolarizing muscle relaxants, such as tubocurarine.
muscle weakness caused by myastenia gravis is temporarily reversed following the administration of neostigmine; used as a diagnostic test.