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neonatal thrombocytopenia |
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neonatal thrombocytopenia A state that is the most common cause of purpura during the neonatal period, defined by platelets < 150,000/µL
Neonatal thrombocytopenia–causes
Platelet consumption
• Immune-mediated Autoimmune, alloimmune–ITP or SLE in mother, platelet antibodies from mother
• Nonimmune Thrombin generation, infections
↓ platelet production Amegakaryocytic thrombocytopenia, aplastic anemia, myeloinfiltrative processes
Others Drugs, hypoxia, inherited metabolic disorders, hypersplenism, associated with giant hemangiomas–Kasabach-Merritt syndrome
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