neonatal lupus


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ne·o·na·tal lu·pus

lupus erythematosus occurring in newborn children of mothers who had lupus during pregnancy; screens to measure anti-SSA antibodies usually should be undertaken; 50% have antinuclear antibodies. Various skin lesions are seen, which can resolve or leave scars; the syndrome usually resolves; however, cardiac manifestations can be fatal. Some children develop lupus erythematosus later in life.

neonatal lupus

Rash, abnormally low platelet counts, liver and brain disease, and congenital heart block occurring in an infant whose mother has systemic lupus erythematosus. The disease results from the passage of maternal autoantibodies to the developing fetus. Although most of the findings resolve spontaneously, congenital heart block does not, and it may require the insertion of a pacemaker.
See also: lupus
References in periodicals archive ?
The antibodies should be measured under the following conditions: 1) suspicion of SLE and primary SS (even if the ANA is negative), 2) mothers of babies with neonatal lupus and congenital heart block, and 3) patients with SLE who are planning to get pregnant.
Neonatal lupus developed in 10 cases, four of which were rash only.
Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside.
Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry.
To determine whether maternal cells might play a role in neonatal lupus syndrome, Stevens and colleagues identified four male infants that had died prior to or shortly after birth from heart damage and whose mothers produced anti-Ro and anti-La antibodies.
The maternal cells were present at much higher levels in the neonatal lupus hearts than in controls.
To further analyze the onset of neonatal lupus syndrome, Stevens is now conducting a study of twins and triplets in which only one of the siblings develops the disease as well as examining whether other organ systems besides the heart may be affected.
Neonatal lupus, he explained, is a serious condition occurring in children whose mothers have anti-Rho/SSA antibodies, which can cross the placenta.
And it has been reported that children with neonatal lupus are at increased risk of developing autoimmune disorders in their first years," he explained.
9) Also, similar to other neonatal lupus syndromes, anti-SS-A antibody in pregnant women places the fetus at high risk for development of complete heart block, one of the possibly fatal complications in neonatal lupus syndrome with an estimated mortality rate of more than 30%.
These statistics have emerged from the ongoing Research Registry for Neonatal Lupus, which now includes more than 300 women.
Among the infants with manifestations of neonatal lupus, 15 had congenital heart block only, three had heart blocks plus a rash, and seven had the rash alone.

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