NEO1

(redirected from neogenin)

NEO1

A gene on chromosome 15q22.3-q23 that encodes a cell surface protein belonging to the immunoglobulin superfamily, the C-terminal internal domain of which shares homology with the tumour suppressor gene DCC and is involved in cell growth, differentiation and cell–cell adhesion.

Molecular pathology
NEO1 mutations are associated with cell proliferation in certain cancers.
References in periodicals archive ?
DCC is functionally related to other dependence receptors such as p75NTR, the androgen receptor, RET, Ptc, UNC5H, and neogenin (Rabizadeh et al.
Neogenin forms a protein complex essential to turning on cartilage-producing genes, the researchers found.
Neogenin, according to the study, helps direct neurons during brain development and aid in regulation of iron levels, and is found throughout bone and cartilage and numerous other tissues.
In adulthood, neogenin may become more of an overseer, keeping tabs on functions it influences, such as bone formation.
Overexpression of neogenin leads to the release of soluble hemojuvelin, whereas suppression of neogenin expression by RNA interference leads to a decrease in the release of soluble hemojuvelin.
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin.
Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin.
In short, there appear to be 2 forms: a GPI-linked cell-associated HJV, which may interact with a transmembrane neogenin receptor to induce changes in hepcidin synthesis in the liver; and a soluble, circulating form derived from skeletal muscle that can serve as an antagonist to disrupt these interactions.
Interaction of HJV with neogenin results in iron accumulation in HEK293 cells.