Louis Immunotherapy targeting radiation-induced neoantigens
, a novel strategy to treat lung cancer
Immune checkpoint blockade relies on a pre-existing inflamed tumor microenvironment and a pre-existing immune response to tumor neoantigens
for clinical activity, which are only present in some patients.
It has also been reported that statins may induce neoantigens
as a result of muscle damage that are subsequently presented to the immune system.
In fact high EGCG bioavailability, resulting in further inhibition of UGT1A1, contributed to the increased concentration of final drug intermediates that could have acted as haptens: protein adducts that may be recognized by the immune system as neoantigens
and immunocyte activation generating a utoantibodies and cell-mediated immune responses (Fig.
The final answer then for the prevention of autoimmune disease is to remove offending food antigens such as gluten from the diet of sensitive individuals; to pay attention to and maintain the balance of the gut microbiota; and to be wary of the viruses, pathogenic bacteria, and toxic chemicals that are responsible for the formation of neoantigens
in our bodies.
There is also evidence in major depression, that O&NS may have changed inactive autoepitopes to neoantigens
, which have acquired immunogenicity and serve as triggers to bypass immunological tolerance, causing (auto)immune responses.
For instance, biliary epithelial cells in biliary atresia has been shown to aberrantly express human leukocyte antigen (HLA) class I and II molecules (12,22,25)--a phenomenon also documented in cases of liver allograft rejection, graft-versus-host disease, and primary biliary cirrhosis (26) and that may have a role in presentation of neoantigens
to naive T lymphocytes.
Might the etiology of at least certain forms of vasculitis be related to generation of neoantigens
in the native vessel, making that vessel the target of a pathogenic immune response?
may be formed on the cell surface by interactions of chemicals with certain cell membrane receptors, or they may be processed, transported to the cell surface, and presented as antigens (Cullen 2005).
Moreover, compared with other therapies, alefacept better retains responses to neoantigens
, potentially including tumor antigens, he said.
Evasion of autologous host cellular immunity is a common feature of tumor cell neoantigens
, because tumor cells are poor antigen-presenting cells.
This can be the result of different posttranslational changes in the tTG molecule or of neoantigens
that occur only in tTG substrate complexes.