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neoantigen

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neoantigen /neo·an·ti·gen/ (-an´tĭ-jen) tumor-associated antigen.
ne·o·an·ti·gen (n-nt-jn)

neoantigen
[-an′tijən]
Etymology: Gk, neos, new, anti, against, genein, to produce
a new specific antigen that develops in a tumor cell.

neoantigen [ne″o-an´tĭ-jen]
an intranuclear antigen, e.g., a T antigen, present in cells infected by oncogenic viruses.

neoantigen
a newly acquired and expressed antigen, e.g. a T antigen, present in cells infected by oncogenic viruses.


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Neoantigens may be formed on the cell surface by interactions of chemicals with certain cell membrane receptors, or they may be processed, transported to the cell surface, and presented as antigens (Cullen 2005).
Evasion of autologous host cellular immunity is a common feature of tumor cell neoantigens, because tumor cells are poor antigen-presenting cells.
[66] Thus, heparins likely form multiple complexes with PF4, and depending on the nature of this interaction, the allosteric modifications in PF4 leading to a neoantigen formation may also vary.
 
 
 
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