I am focused on methods combining immunohistochemical analysis of the tumour microenvironment, tumour sequencing and neoantigen
prediction, and transcriptional signatures of response.
TM)] analysis with its proprietary bioinformatics neoantigen prediction pipeline specifically designed for immuno-oncology applications.
The exquisite tumor specificity of neoantigens makes them good targets for immunotherapy.
14) Gliadin can serve as a substrate of transglutaminase, which is activated upon injury or inflammation of the small bowel, and in the process becomes cross-linked to transglutaminase, thereby creating a neoantigen
, which induces an immune response to the self-protein (transglutaminase).
The abnormal matrix and advanced glycosylated end products create a neoantigen
that triggers a secondary auto-immune reaction and B-cell proliferation and auto-antibody formation (6), (7)
Expression, detection and assay of a neoantigen
(Neo-CRP) associated with a free, human C-reactive protein subunit.
COPENHAGEN -- Reduced responses to pneumococcal polysaccharide and neoantigen
vaccination in rheumatoid arthritis patients who were treated with rituximab and methotrexate suggest that polysaccharide and primary immunizations should be administered before rituximab infusions to maximize their efficacy, Dr.
66] Thus, heparins likely form multiple complexes with PF4, and depending on the nature of this interaction, the allosteric modifications in PF4 leading to a neoantigen
formation may also vary.
One proposed explanation is the formation of a metabolite that is either haptogenic or alters an hepatocyte macromolecule to generate a neoantigen
Project title: Personal neoantigen
vaccination for early CLL Lucio Castilla , Ph.
PSA is not a neoantigen
or cancer-specific antigen, but rather is expressed by normal, benign hyperplastic, and neoplastic prostatic cells as well other nonprostatic tissues .
Profiling the T-cell repertoire is also being widely incorporated into clinical studies to assess the efficacy of treatments specifically designed to induce an immune response to cancer, including checkpoint inhibitors such as anti-CTLA, dendritic cell vaccines, and vaccination with patient-specific tumor-derived neoantigens