nelfinavir


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Related to nelfinavir: saquinavir, ritonavir

nelfinavir

 [nel-fin´ah-vir]
an HIV protease inhibitor used as the mesylate salt in treatment of human immuno deficiency virus infection and acquired immunodeficiency syndrome; administered orally.

nelfinavir

/nel·fin·a·vir/ (nel-fin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the mesylate salt in the treatment of HIV infection.

nelfinavir

(nĕl-fĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its mesylate, often with other drugs, to suppress the replication of HIV.

nelfinavir

an antiviral.
indications It is used alone or in combination with other drugs to treat HIV.
contraindication Known hypersensitivity to protease inhibitors prohibits its use.
adverse effects Life-threatening effects include anemia, leukopenia, thrombocytopenia, and hemoglobin abnormalities. Other adverse effects include anorexia, dyspepsia, headache, asthenia, poor concentration, dermatitis, pain, bleeding, hypoglycemia, and hyperlipidemia. Common side effects include diarrhea, flatulence, and rash.

nelfinavir

A potent HIV protease inhibitor, which is combined with reverse transcriptase inhibitors—e.g., Retrovir (AZT), zidovudine and Epivir (3TC, lamivudine)—acting at late stages in the HIV life cycle.
 
Side effects
Diarrhoea, 20%, increased liver function tests (LFTs), lipodystrophy.
 
Contraindicated drugs
Nelfinavir inhibits the cytochrome P-450 system, precluding co-administration of agents (e.g., amiodarone, astemizole, cisapride, ergot derivatives, midazolam, quinidine, rifampin, terfenadine, triazolam) which are metabolised by the P-450 system.

nelfinavir

Viracept® AIDS A potent HIV protease inhibitor, used with reverse transcriptase inhibitors–eg, Retrovir–AZT, zidovudine and Epivir–3TC, lamivudine; it acts at late stages in the viral life cycle Side effects Diarrhea–20%, ↑ LFTs, lipodystrophy. See AIDS, Antiretroviral, HIV, Protease inhibitors. Cf Reverse transcriptase inhibitor.

nelfinavir

A protease inhibitor drug used in combination with other antiretroviral drugs to treat HIV infections. The drug is on the WHO official list. A brand name is Viracept.
References in periodicals archive ?
Liu and his team plucked nelfinavir from the Johns Hopkins Drug Library, which contains information on many existing FDA-approved drugs.
Burger DM, Schwietert HR, Colbers EP, Becker M: The effect of the CYP2C19*2 heterozygote genotype on the pharmacokinetics of nelfinavir.
Pharmacokinetics of nelfinavir and its active metabolite, hydroxy-tert-butylamide, in infants perinatally infected with human immunodeficiency virus type 1.
Fenofibrate is partially biotransformed by glucuronidation and may interact with nelfinavir or ritonavir.
ACTG 389 compared boosted saquinavir, boosted indinavir, nelfinavir and placebo all dosed twice daily in a large randomised study [10].
Tests on batches of the drug, whose generic name is nelfinavir, revealed higher than normal quantities of methane sulfonic acid ethyl ester.
Nelfinavir, a less potent protease inhibitor that has fallen out of favor, also is an option.
41) Results from one small-scale study indicated that administration of a single 25-mg dose of sildenafil did not alter the steady-state pharmacokinetics of the protease inhibitors nelfinavir, indinavir, or ritonavir-boosted saquinavir.
Usually this consists of a standard regimen of a combination of antiretrovirals such as zidovudine, lamivudine and nelfinavir.
Nelfinavir mesylate shows a "dramatic drop" in 7-day plasma levels when given with methadone.
At baseline, 28 children started HAART that included indinavir and 3 started HAART that included nelfinavir (Clin.
Los analogos nucleosidos inhibidores de la transcriptasa reversa mas usados son la zidovudina y la lamivudina; el analogo no nucleosido inhibidor de la transcriptasa reversa es la nevirapina y el inhibidor de la proteasa de mayor uso es el nelfinavir.