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an HIV protease inhibitor used as the mesylate salt in treatment of human immuno deficiency virus infection and acquired immunodeficiency syndrome; administered orally.
nelfinavir/nel·fin·a·vir/ (nel-fin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the mesylate salt in the treatment of HIV infection.
A protease-inhibiting drug given in the form of its mesylate, often with other drugs, to suppress the replication of HIV.
indications It is used alone or in combination with other drugs to treat HIV.
contraindication Known hypersensitivity to protease inhibitors prohibits its use.
adverse effects Life-threatening effects include anemia, leukopenia, thrombocytopenia, and hemoglobin abnormalities. Other adverse effects include anorexia, dyspepsia, headache, asthenia, poor concentration, dermatitis, pain, bleeding, hypoglycemia, and hyperlipidemia. Common side effects include diarrhea, flatulence, and rash.
nelfinavirA potent HIV protease inhibitor, which is combined with reverse transcriptase inhibitors—e.g., Retrovir (AZT), zidovudine and Epivir (3TC, lamivudine)—acting at late stages in the HIV life cycle.
Diarrhoea, 20%, increased liver function tests (LFTs), lipodystrophy.
Nelfinavir inhibits the cytochrome P-450 system, precluding co-administration of agents (e.g., amiodarone, astemizole, cisapride, ergot derivatives, midazolam, quinidine, rifampin, terfenadine, triazolam) which are metabolised by the P-450 system.