nelfinavir /nel·fin·a·vir/ (nel-fin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the mesylate salt in the treatment of HIV infection.
nelfinavir,
nelfinavir
nel·fin·a·vir (n l-f n  -vîr)n. A protease-inhibiting drug usually used in combination with other drugs to suppress the replication of HIV. |
nelfinavir,
an antiviral.
indications It is used alone or in combination with other drugs to treat HIV.
contraindication Known hypersensitivity to protease inhibitors prohibits its use.
adverse effects Life-threatening effects include anemia, leukopenia, thrombocytopenia, and hemoglobin abnormalities. Other adverse effects include anorexia, dyspepsia, headache, asthenia, poor concentration, dermatitis, pain, bleeding, hypoglycemia, and hyperlipidemia. Common side effects include diarrhea, flatulence, and rash.
nelfinavir
Viracept® AIDS A potent HIV protease inhibitor, used with reverse transcriptase inhibitors–eg, Retrovir–AZT, zidovudine and Epivir–3TC, lamivudine; it acts at late stages in the viral life cycle
Side effects Diarrhea–20%, ↑ LFTs, lipodystrophy. See AIDS, Antiretroviral, HIV, Protease inhibitors. Cf Reverse transcriptase inhibitor.
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