Bexsero[R] contains four immunodominant antigens: fHbp, PorA, NadA and neisserial
heparin binding antigen (NHBA) (Bai et al, 2011).
The septic shock caused by Neisserial
invasive disease is characterized by the presence of skin lesions (petecchial rashes and purpura).
Multilocus sequence typing and genotypic analysis of PorA variable regions (VRs) (porA VR1 and VR2), ferric enterochelin receptor VR (fetA), neisserial heparin-binding antigen (nhba), neisserial adhesin A (nadA), and factor H binding protein (fhbp) encoding regions were performed by using described protocols (11,12).
NadA is a surface-exposed neisserial adhesin that binds human [beta]1-intergrins (34) and is involved in epithelial cell adhesion and invasion (32,33).
Other known genes in this pathway, however, are absent from the sequenced neisserial genomes.
These include genes encoding proteins involved in obtaining iron from the host (fbpC and lbpB); genes that code for proteins involved in the formation of pili, neisserial surface structures that are important for motility and attachment to host cells (pilC, pilT, pilQ, pilS, and pilW); and genes coding for additional adhesins (nadA, opa).
Deficiency of the complement component, C3, leads to repeated sinopulmonary infections similar to agammaglobulinemia, while deficiencies in the terminal complement components (C6, C7, C8, C9) result in recurrent systemic infections or meningitis with neisserial
This study found that the Company's Neisserial
porins, particularly PorB, are capable of inserting themselves into host cells thereby creating a potential mechanism to impede the initial phases of bacterial infection.
The most well-known example is the susceptibility of patients with terminal complement component deficiencies to neisserial