By flow cytometry, the outbreak strain had low expression of factor H binding protein and low binding with antisera to the Neisserial
heparin binding antigen included in Bexsero (Table) (7).
MenB-4C consists of three recombinant proteins (neisserial
adhesion A [NadA], factor H binding protein [FHbp] fusion protein, and neisserial
heparin binding antigen [NHBA] fusion protein) and outer membrane vesicles (OMVs) containing outer membrane protein PorA serosubtype P1.
Bexsero[R] contains four immunodominant antigens: fHbp, PorA, NadA and neisserial
heparin binding antigen (NHBA) (Bai et al, 2011).
The septic shock caused by Neisserial
invasive disease is characterized by the presence of skin lesions (petecchial rashes and purpura).
Other known genes in this pathway, however, are absent from the sequenced neisserial
Because serogroup distributions vary by country, the vaccine in the United Kingdom protects against group C Neisserial
meningitidis, while the U.
Deficiency of the complement component, C3, leads to repeated sinopulmonary infections similar to agammaglobulinemia, while deficiencies in the terminal complement components (C6, C7, C8, C9) result in recurrent systemic infections or meningitis with neisserial
Bexsero includes 4 different components: an FHbp of variant 1 (subfamily B); a Neisseria adhesion A protein (NadA); a neisserial
heparin-binding antigen (NhbA); and outer membrane vesicles from a serogroup B strain containing PorA P1.
MenB-4C consists of three recombinant proteins (Neisserial
adhesin A [NadA], factor H binding protein [FHbp] fusion protein, and Neisserial
Heparin Binding Antigen [NHBA] fusion protein), and outer membrane vesicles (OMVs) containing outer membrane protein PorA serosubtype P1.
Multilocus sequence typing and genotypic analysis of PorA variable regions (VRs) (porA VR1 and VR2), ferric enterochelin receptor VR (fetA), neisserial
heparin-binding antigen (nhba), neisserial
adhesin A (nadA), and factor H binding protein (fhbp) encoding regions were performed by using described protocols (11,12).
Use of neisserial
lipoprotein (Lip) for subtyping Neisseria gonorrhoeae.
The most well-known example is the susceptibility of patients with terminal complement component deficiencies to neisserial