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negative sense

   Also found in: Wikipedia 0.02 sec.
negative sense
in RNA viruses, the genomic RNA is of opposite polarity, 5' to 3', to messenger RNA so that after adsorption, penetration, uncoating and release of the viral RNA into the cytoplasm of the cell, the viral RNA must first be transcribed to produce messenger RNAs which is initially accomplished by a RNA dependent RNA polymerase that is a structural component of the virus and released along with the viral RNA.
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