Pretransplant donor-specific antibodies in cytotoxic negative crossmatch
kidney transplants: are they relevant?
Once a donor organ becomes available, the unacceptable antigen profile helps determine which candidate recipients have a high likelihood of a negative crossmatch
To qualify for this type of experimental kidney transplant, the donor and recipient pairs must be blood-type compatible and have a negative crossmatch
, which means that testing has been done to confirm the recipient docs not have antibodies in the blood that would cause rejection of the kidney.
We compared the MFIs of the single-antigen beads (which predicted the flow crossmatch as positive) with actual positive or negative crossmatch
results for both T (class 1) and B (class 2) cell flow cytometric crossmatches (Fig.